Re-evaluation of hyaluronidase in peribulbar anaesthesia
Autor: | T Mian, M Y Khan, D P Prosser, G E Rodney, H M Jones |
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Rok vydání: | 1997 |
Předmět: |
Adult
Male medicine.medical_specialty Peribulbar anesthesia Lidocaine medicine.drug_class Hyaluronoglucosaminidase Cataract Extraction Cellular and Molecular Neuroscience Double-Blind Method Hyaluronidase Humans Medicine Local anesthesia Anesthetics Local Aged Bupivacaine Aged 80 and over Local anaesthetic Local anesthetic business.industry Middle Aged Sensory Systems Confidence interval Surgery Ophthalmology Anesthesia Female business Anesthesia Local Research Article medicine.drug |
Zdroj: | American Journal of Ophthalmology. 123:281 |
ISSN: | 0002-9394 |
DOI: | 10.1016/s0002-9394(14)71066-9 |
Popis: | AIMS/BACKGROUND: Hyaluronidase can augment the actions of local anaesthetics in peribulbar anaesthesia. However, evidence suggests satisfactory anaesthesia can be achieved using mixtures without hyaluronidase. A randomised double blind study was conducted on 50 patients, undergoing peribulbar anaesthesia, to validate this observation. METHODS: Patients received a standard mixture of local anaesthetic (0.5% bupivacaine and 2% lignocaine in a 1:1 ratio) with or without hyaluronidase (25 IU/ml of mixture), pH values 5.16 and 5.24 respectively. Time taken to establish satisfactory anaesthesia to allow surgery was noted. RESULTS: The onset time to globe akinesia in the control group ranged from 2 to 15 minutes (mean 5.64 and median 4 minutes) and in the hyaluronidase group from 2 to 12 minutes (mean 4.64 and median 4 minutes). The volume of local anaesthetic injected to achieve satisfactory anaesthesia ranged from 8 to 16 ml (mean 10.96, SD 1.95) in the control group and 10 to 18 ml (mean 11.64, SD 2.8) in the hyaluronidase group. A Mann-Whitney test to compare onset times to globe akinesia between groups gave a p value = 0.6 and 95% confidence interval (-1 to 2 minutes). CONCLUSION: Addition of 25 IU/ml of hyaluronidase to a standard pH unadjusted local anaesthetic mixture does not significantly reduce the time to the onset of satisfactory globe akinesia. |
Databáze: | OpenAIRE |
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