Effects of the Concomitant Use of Low-dose Clarithromycin with an Anti-TNFα Antibody in a Patient with Intestinal Behçet Disease
| Autor: | Tadashi Ikegami, Shoichiro Yara, Takeshi Hirayama, Yasushi Matsuzaki, Naoki Konishi, Akira Honda, Junichi Iwamoto, Hajime Ueda, Tadakuni Monma, Masashi Murakami |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Prednisolone Anti-Inflammatory Agents Case Report PSL Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Mesalazine Refractory Internal medicine Clarithromycin Internal Medicine medicine Adalimumab Weaning Cecal Diseases Humans Mesalamine Ulcer Aged business.industry Ileal Diseases Behcet Syndrome General Medicine clarithromycin digestive system diseases intestinal Behçet disease chemistry anti-TNFα antibody 030220 oncology & carcinogenesis Concomitant 030211 gastroenterology & hepatology Drug Therapy Combination business medicine.drug |
| Zdroj: | Internal Medicine |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | A 66-year-old Japanese male with a history of Behcet disease exhibited oral and genital ulcers, and a round deep ileocecal ulcer. He was treated with a combination of mesalazine and 20 mg/day of prednisolone (PSL), but was only partially responsive to PSL and we were not able to reduce the steroid dosage. Adalimumab was also administered. However, the ulcer was not completely responsive, and weaning the patient off PSL remained impossible. In contrast, additional treatment with clarithromycin completely healed the refractory active ulcer and left only a scar. Furthermore, the ulcer has since maintained the scar stage despite successfully weaning the patient from PSL. |
| Databáze: | OpenAIRE |
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