Cryopreserved amniotic membrane and umbilical cord particulate for managing pain caused by facet joint syndrome
| Autor: | Daniel S. Bennett |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty facet joint syndrome Treatment outcome Observational Study Umbilical cord Zygapophyseal Joint Cryopreservation Injections Intra-Articular Umbilical Cord 03 medical and health sciences 0302 clinical medicine Managing pain facet joint medicine Back pain Humans Pain Management Amnion 030212 general & internal medicine Aged Monitoring Physiologic Pain Measurement Retrospective Studies intra-articular injection Biological Products amniotic membrane business.industry General Medicine Middle Aged musculoskeletal system lower back pain Surgery Treatment Outcome Chronic disease medicine.anatomical_structure Facet joint syndrome 030220 oncology & carcinogenesis Chronic Disease Female medicine.symptom business Low Back Pain Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| DOI: | 10.1097/md.0000000000014745 |
| Popis: | Treatment of back pain due to facet joint syndrome has been a challenge for physicians since its recognition ∼80 years ago. Intra-articular injections of steroids, local anesthetics, and phenol have been widely adopted despite their known shortcomings. Recently, intra-articular injection of amniotic membrane-umbilical cord (AMUC) has been utilized in various orthopedic indications, including those involving synovial joints, due to its reported anti-inflammatory properties. Herein, use of AMUC for facet joint syndrome was evaluated. A single-center case series was conducted on patients presenting with pain caused by facet joint syndrome, confirmed by single blocking anesthetic injection and treated using a single intra-articular injection of 50 mg particulate AMUC (CLARIX FLO) suspended in preservative-free saline. Patient reported back pain severity (numerical scale 0–10) and opioid use were compared between baseline and 6 months following treatment. A total of 9 patients (7 males, 2 females), average age 52.1 ± 15.9 years, were included. Five patients with cervical pain had a history of trauma, 1 patient had suffered lumbar facet injury and 3 had degenerative lumbar facet osteoarthritis. All patients had severe pain prior to injection (8.2 ± 0.8) and 4 (44%) were taking opioids (>100 morphine milligram equivalents). Six-month post-treatment, average pain had decreased to 0.4 ± 0.7 (P |
| Databáze: | OpenAIRE |
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