Distinct Manifestations of Cooperative, Multidimensional Stimulus Representations in Different Auditory Forebrain Stations
| Autor: | Kexin Yuan, Craig A. Atencio, Christoph E. Schreiner, Jonathan Y. Shih |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cognitive Neuroscience spectrotemporal receptive fields cat Action Potentials Stimulus (physiology) Biology Auditory cortex transformations 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Prosencephalon Psychology Animals Auditory Cortex Spectral integration Neurosciences Experimental Psychology Medial geniculate body auditory forebrain 030104 developmental biology multiple filters Acoustic Stimulation Receptive field Forebrain Auditory Perception Cats Auditory information Cognitive Sciences Original Article predictions Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cereb Cortex Cerebral cortex (New York, N.Y. : 1991), vol 30, iss 5 |
| Popis: | Classic spectrotemporal receptive fields (STRFs) for auditory neurons are usually expressed as a single linear filter representing a single encoded stimulus feature. Multifilter STRF models represent the stimulus-response relationship of primary auditory cortex (A1) neurons more accurately because they can capture multiple stimulus features. To determine whether multifilter processing is unique to A1, we compared the utility of single-filter versus multifilter STRF models in the medial geniculate body (MGB), anterior auditory field (AAF), and A1 of ketamine-anesthetized cats. We estimated STRFs using both spike-triggered average (STA) and maximally informative dimension (MID) methods. Comparison of basic filter properties of first maximally informative dimension (MID1) and second maximally informative dimension (MID2) in the 3 stations revealed broader spectral integration of MID2s in MGBv and A1 as opposed to AAF. MID2 peak latency was substantially longer than for STAs and MID1s in all 3 stations. The 2-filter MID model captured more information and yielded better predictions in many neurons from all 3 areas but disproportionately more so in AAF and A1 compared with MGBv. Significantly, information-enhancing cooperation between the 2 MIDs was largely restricted to A1 neurons. This demonstrates significant differences in how these 3 forebrain stations process auditory information, as expressed in effective and synergistic multifilter processing. |
| Databáze: | OpenAIRE |
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