Comparison between acoustic radiation force impulse quantification data and perfusion-CT parameters in hepatocellular carcinoma
| Autor: | Marius Horger, S. Schneeweiß, Mustafa Kurucay, Konstantin Nikolaou, Christer Ruff, Michael Esser, Manuel Kolb |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Carcinoma Hepatocellular Cirrhosis Perfusion scanning Blood volume 030218 nuclear medicine & medical imaging 03 medical and health sciences Elasticity Imaging Techniques 0302 clinical medicine medicine Humans Radiology Nuclear Medicine and imaging Aged Ultrasonography Aged 80 and over Blood Volume Neovascularization Pathologic medicine.diagnostic_test business.industry Liver Neoplasms General Medicine Blood flow Cone-Beam Computed Tomography Middle Aged medicine.disease Elasticity 030220 oncology & carcinogenesis Hepatocellular carcinoma Female Radiology Elastography Nuclear medicine business Perfusion |
| Zdroj: | European Journal of Radiology. 89:215-220 |
| ISSN: | 0720-048X |
| DOI: | 10.1016/j.ejrad.2017.02.014 |
| Popis: | Objective To find out, if ultrasound elastography of hepatocellular carcinoma (HCC) can predict patterns of tumor perfusion in volume perfusion computed tomography (VPCT). Material and methods 25 consecutive patients (mean age, 68.9; range, 51–85 years) with liver cirrhosis suspected of HCC underwent VPCT and acoustic radiation force impulse (ARFI) elastography the same day. Quantitative elasticity values were registered, while blood flow (BF), blood volume (BV) and hepatic perfusion index (HPI) of the HCC lesions were calculated. Additionally, we identified histologic WHO grading, lesion size and localization. The Siemens Acuson S 3000 HELX-System with Virtual Touch™-Software and Siemens Somatom Definition Flash with Syngo ® software were used. Results A total of 43 HCC lesions were assessed. Mean shear wave velocity was 2.6 m/s (range, 1.1–4.3 m/s). There was no significant linear correlation between the elasticity values and BF (p = 0.751), BV (p = 0.426) and HPI (p = 0.437). However, elasticity values were higher, the larger the tumor was (p = 0.008). Shear wave velocity declined with increasing distance of the HCC to the skin surface (p = 0.028) and depending on liver segment. In addition, elasticity values were higher in less differentiated HCCs. This trend was not statistically significant (p = 0.842). Conclusion Tissue elasticity in HCC does not correlate with the degree of tumor vascularization, but calculated values are influenced both by the tumor size and localization inside the liver. |
| Databáze: | OpenAIRE |
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