Lower macrophage recruitment and atherosclerosis resistance in FVB mice
| Autor: | Gideon Halperin, M. Ben-Naim, Y. Dabach, Yechezkiel Stein, Olga Stein |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
CCR2 Ratón Aorta Thoracic Biology Muscle Smooth Vascular Mice chemistry.chemical_compound Downregulation and upregulation Internal medicine medicine Animals Macrophage Liver X receptor Chemokine CCL2 Phospholipids Mice Inbred BALB C Mice Inbred C3H Mice Inbred NZB Cholesterol Monocyte Atherosclerosis Mice Inbred C57BL Disease Models Animal medicine.anatomical_structure Endocrinology chemistry Immunology Disease Progression Macrophages Peritoneal lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine Blood vessel |
| Zdroj: | Atherosclerosis. 189:336-341 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2006.01.019 |
| Popis: | The aim of this study was to compare some aspects of cholesterol accretion and cholesterol efflux in cellular components of the aortic wall derived from mice resistant or susceptible to atherosclerosis, FVB or C57BL, respectively. Cholesterol efflux, from cholesterol loaded smooth muscle cells or elicited macrophages, to apo A–I or HDL was similar in the two strains under basal conditions, and after cAMP or LXR upregulation. Recruitment of peritoneal macrophages, 3 days after thioglycollate injection, was 65% lower in FVB than in C57BL mice, commensurate with a 40% reduction in MCP-1 in peritoneal lavage. In additional three atherosclerosis resistant strains, NZB, A/J and 129(SvJ), macrophage recruitment was reduced to a similar extent despite high MCP-1 levels. Since impaired macrophage recruitment in CCR2 −/− or MCP-1 −/− C57BL mice was reported to reduce atherosclerosis, it seems plausible that in some mouse strains reduction in macrophage mobilization could contribute to atherosclerosis resistance. |
| Databáze: | OpenAIRE |
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