Evaluation of the effect of ambrisentan on digital microvascular flow in patients with systemic sclerosis using laser Doppler perfusion imaging: a 12-week randomized double-blind placebo controlled trial

Autor: Nilanjana Bose, James Bena, Soumya Chatterjee
Rok vydání: 2014
Předmět:
Male
Time Factors
Placebo-controlled study
Perfusion scanning
Pilot Projects
law.invention
0302 clinical medicine
Randomized controlled trial
law
Laser-Doppler Flowmetry
Immunology and Allergy
030212 general & internal medicine
Prospective Studies
skin and connective tissue diseases
integumentary system
Phenylpropionates
Laser Doppler velocimetry
Middle Aged
3. Good health
Pyridazines
Cardiology
Female
Endothelin receptor
medicine.drug
Research Article
Adult
medicine.medical_specialty
Ambrisentan
Perfusion Imaging
Immunology
Ischemia
Fingers
03 medical and health sciences
Young Adult
Rheumatology
Double-Blind Method
Internal medicine
medicine
Humans
Aged
030203 arthritis & rheumatology
Scleroderma
Systemic
Dose-Response Relationship
Drug
business.industry
Microcirculation
Blood flow
medicine.disease
Surgery
Regional Blood Flow
business
Follow-Up Studies
Zdroj: Arthritis Research & Therapy
ISSN: 1478-6362
Popis: Introduction In patients with systemic sclerosis (SSc), digital ischemia results from an occlusive microvasculopathy that may not respond adequately to conventional vasodilators. Endothelin receptor antagonists can potentially modify the fibroproliferative vascular remodeling in SSc, and hence their use may be justified in the management of digital ischemia. The objective of this clinical trial was to evaluate the effect of ambrisentan, a selective endothelin type A receptor antagonist, on microvascular blood flow in patients with limited systemic sclerosis (SSc) using laser Doppler perfusion imaging (LDPI). Methods In this randomized, double-blind, placebo controlled study we enrolled 20 patients with limited SSc. Fifteen patients received ambrisentan 5 mg daily for one month and then 10 mg daily for two months, and five received a placebo. There were three visits: weeks 0 (baseline), one and 12. Three patient-oriented questionnaires were completed at each visit: Scleroderma-Health Assessment Questionnaire (S-HAQ), Raynaud Condition Score (RCS), and Pain-Visual Analog Scale (P-VAS). At each visit, LDPI was used to obtain three blood flow readings involving regions of interest in second to fifth fingers of the non-dominant hand at room temperature (25°C) and after cooling (10°C) for two minutes. Results There were 16 females (80%); mean age was 50 years. None of the differences in blood flow (as measured by LDPI) were significant both at baseline and after cooling. However, patients in the ambrisentan group showed significant improvement in the patient-oriented outcomes: RCS (P = 0.001) and S-HAQ score (P = 0.005). Conclusions This pilot study did not show evidence of significant increase in digital blood flow over time; however, there was an improvement in RCS and S-HAQ score. We conclude that continuous use of ambrisentan for three months does not seem to significantly improve digital blood flow in SSc patients. Trial registration Clinicaltrials.gov NCT01072669. Registered 19 February 2010. Electronic supplementary material The online version of this article (doi:10.1186/s13075-015-0558-9) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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