Synthesis and characterization of copper (II) octaazamacrocyclic complexes with glycine derivatives. In vitro antiproliferative and antimicrobial evaluation of Cu(II) and Co(II) analogous
| Autor: | Branka Dražić, Slađana Tanasković, Mirjana Antonijević Nikolić, Željko Žižak |
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| Rok vydání: | 2020 |
| Předmět: |
antiproliferative activity
Stereochemistry Cyclohexane conformation chemistry.chemical_element Antiproliferative activity Bacillus subtilis Antimicrobial activity 010402 general chemistry medicine.disease_cause 01 natural sciences lcsh:Chemistry HeLa octaazamacrocycle medicine Escherichia coli antimicrobial activity cu(ii) and co(ii) complexes biology 010405 organic chemistry Cu(II) and co(II) complexes Octaazamacrocycle General Chemistry biology.organism_classification Copper In vitro 3. Good health 0104 chemical sciences lcsh:QD1-999 chemistry Glycine Macrocyclic ligand |
| Zdroj: | Journal of the Serbian Chemical Society Journal of the Serbian Chemical Society, Vol 85, Iss 5, Pp 637-649 (2020) |
| ISSN: | 1820-7421 0352-5139 |
| Popis: | Two new complexes with the general formula [Cu2(L)tpmc] (ClO4)3·nH2O (tpmc = N,N′,N′′,N′′′-tetrakis(2-pyridylmethyl)- -1,4,8,11-tetraazacyclotetradecane, L = N-methylglycine, n = 3; L = N,N- -dimethylglycine, n = 2) were isolated and their composition, some physical and chemical properties and geometries were proposed based on elemental analysis (C, H, N), conductometric and magnetic measurements and spectroscopic data (UV–Vis, FTIR). It is evident that the complexes are binuclear and an exo coordination mode of the macrocyclic ligand in the boat conformation was proposed. The co-ligands are coordinated as a bridge using both oxygen atoms of the OCO- group. The cytotoxic activity of Cu(II) complexes as well as their Co(II) analogs, the starting ligands and the free salts were tested against human cervix adenocarcinoma cell line (HeLa), human chronic myelogenous leukemia cells (K562), human breast cancer cell line (MDA-MB-453), and a non-cancerous cell line, human embryonic lung fibroblast (MRC-5). The IC50 values for the Cu(II) complexes were from 21.6±0.04 to 66.1±0.8, and for the Co(II) analogs were within the range from 8.8±0.74 to 15.40±1.52. All four complexes were tested for their antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and the yeast Candida albicans. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 172014] |
| Databáze: | OpenAIRE |
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