Distinct roles for interleukin-12p40 and tumour necrosis factor in resistance to oral candidiasis defined by gene-targeting
| Autor: | S. Riminton, Camile S. Farah, Robert B. Ashman, Yan Hu |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Microbiology (medical)
medicine.medical_treatment Immunology Kidney Microbiology Oropharyngeal Candidiasis Interferon-gamma Mice Th2 Cells Candidiasis Oral Candida albicans medicine Animals General Dentistry Gene knockout Mice Knockout Immunity Cellular biology Interleukin-12 Subunit p40 Tumor Necrosis Factor-alpha Mouth Mucosa Brain Interleukin Th1 Cells medicine.disease biology.organism_classification Interleukin-12 Immunity Innate Interleukin-10 Specific Pathogen-Free Organisms Protein Subunits Cytokine Gene Targeting Knockout mouse Female Tumor necrosis factor alpha Disease Susceptibility Interleukin-4 Systemic candidiasis Fungemia |
| Zdroj: | Oral Microbiology and Immunology. 21:252-255 |
| ISSN: | 1399-302X 0902-0055 |
| DOI: | 10.1111/j.1399-302x.2006.00288.x |
| Popis: | Cell-mediated immunity is important for anti-Candida host defence in mucosal tissues. In this study we used cytokine-specific gene knockout mice to investigate the requirement for T helper type 1 (Th1) and Th2 cytokines in recovery from oral candidiasis. Knockout mice used in this study included interleukin-4 (IL-4), IL-10, IL-12p40, interferon-gamma (IFN-gamma), and tumour necrosis factor (TNF). The mice were challenged either orally or systemically with Candida albicans yeasts, and levels of colonization were determined. IL-12p40 knockout mice developed chronic oropharyngeal candidiasis, but were not more susceptible to systemic challenge. On the other hand, TNF knockout mice displayed increased susceptibility to both oral and systemic challenge, but only in the acute stages of infection. TNF apparently has a protective effect in the acute stages of both oral and systemic candidiasis, whereas IL-12p40 is essential for recovery from oral but not systemic candidiasis. The role of IL-12p40, and its relation to T-cell-mediated responses remain to be determined. |
| Databáze: | OpenAIRE |
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