Onchocerca volvulus: The Road from Basic Biology to a Vaccine
Autor: | Maria Elena Bottazzi, David Abraham, Benjamin L. Makepeace, Peter J. Hotez, Simon A. Babayan, Sara Lustigman, Thomas R. Klei |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Drug Resistance Article 03 medical and health sciences Drug treatment Ivermectin Onchocerciasis Ocular Animals Humans Medicine Mass drug administration Intensive care medicine Vaccines Antiparasitic Agents Blindness biology business.industry medicine.disease biology.organism_classification Onchocerca volvulus 030104 developmental biology Infectious Diseases Immunology Neglected tropical diseases Parasitology business Onchocerciasis medicine.drug |
Zdroj: | TRENDS IN PARASITOLOGY |
Popis: | Human onchocerciasis - commonly known as river blindness - is one of the most devastating yet neglected tropical diseases, leaving many millions in sub-Saharan Africa blind and/or with chronic disabilities. Attempts to eliminate onchocerciasis, primarily through the mass drug administration of ivermectin, remains challenging and has been heightened by the recent news that drug-resistant parasites are developing in some populations after years of drug treatment. Needed, and needed now, in the fight to eliminate onchocerciasis are new tools, such as preventive and therapeutic vaccines. This review summarizes the progress made to advance the onchocerciasis vaccine from the research laboratory into the clinic. |
Databáze: | OpenAIRE |
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