Ascaris hemoglobin gene: plant-like structure reflects the ancestral globin gene
| Autor: | Andrew P. Kloek, Daniel E. Goldberg, B R Krishnan, B Guinn, David R. Sherman |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Molecular Sequence Data
Sequence alignment Genes Plant Polymerase Chain Reaction Molecular evolution hemic and lymphatic diseases Complementary DNA Animals Amino Acid Sequence Globin Gene Ascaris suum Genetics Multidisciplinary Base Sequence biology Ascaris Intron DNA biology.organism_classification Biological Evolution Introns Globins Genes Oligodeoxyribonucleotides Sequence Alignment Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences. 89:11696-11700 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.89.24.11696 |
| Popis: | Animal globin genes have two introns at strictly conserved positions, while plant globin genes have both of these as well as an additional, central intron. It has been proposed that a common ancestor gene had three introns, one of which was subsequently lost from animal but not plant globin genes. We have elucidated the cDNA sequence and gene structure of a hemoglobin from the parasitic nematode Ascaris suum and found a plant-like central intron, providing strong evidence for a three-intron ancestor of modern globin genes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|