TheMTHFD1c.1958 G>A polymorphism and recurrent spontaneous abortions
| Autor: | Tania O Crişan, Marius F. Farcaş, Adrian P. Trifa, Mihai G. Netea, Mariela S. Militaru, Radu A. Popp, Ioan Victor Pop |
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| Rok vydání: | 2010 |
| Předmět: |
Methylenetetrahydrofolate Dehydrogenase (NADP)
Genetics Abortion Habitual business.industry Case-control study MTHFD1 Obstetrics and Gynecology Trifunctional enzyme Polymorphism Single Nucleotide Minor Histocompatibility Antigens Andrology Case-Control Studies Pediatrics Perinatology and Child Health Humans Medicine SNP Female In patient Allele business MTHFD1 gene Allele frequency |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 24:189-192 |
| ISSN: | 1476-4954 1476-7058 |
| DOI: | 10.3109/14767051003702794 |
| Popis: | Objective. Our aim was to evaluate the possible association between recurrent spontaneous abortions (RSA) and the c.1958 G>A SNP in the MTHFD1 gene encoding a trifunctional enzyme involved in DNA synthesis and folate metabolism.Methods. By the means of PCR-RFLP we genotyped 131 women with a history of at least two consecutive spontaneous abortions and a matched number of controls.Results. Our findings show an allele frequency of 44.3% of the A allele and 55.7% of the G allele in patients and 42.4% of the A allele and 57.6% of the G allele in controls.Conclusions. No major difference between cases and controls was revealed, therefore, it is unlikely that this SNP plays a major role in RSA. |
| Databáze: | OpenAIRE |
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