Thin-Glomerular-Basement-Membrane Nephropathy

Autor:	Gandhi, S., Kamyar Kalantar-Zadeh, Don, B. R.
Rok vydání:	2002
Předmět:	Collagen Type IV Male Mutation Humans Female Renal Insufficiency General Medicine Prognosis Glomerulonephritis Membranous Basement Membrane Aged Genes Dominant Hematuria
Zdroj:	Europe PubMed Central Scopus-Elsevier
ISSN:	0038-4348
DOI:	10.1097/00007611-200207000-00023
Popis:	Thin-glomerular-basement-membrane (TGBM) nephropathy is among the most common causes of isolated hematuria. This autosomal dominant disorder is characterized by diffuse thinning of the GBM and is diagnosed by electron microscopic examination of renal biopsy tissue. A study of an affected kindred has revealed a mutation in the alpha chain of type IV collagen, resulting in abnormal basement membrane synthesis. Although the exact prevalence and prognosis is unclear, TGBM is usually regarded as a benign cause of hematuria and not associated with any untoward effect on renal function. We report a case of TGBM nephropathy, with associated proteinuria and progressive renal insufficiency. Other studies similarly contend that TGBM nephropathy may not be so benign. On the basis of these findings, we suggest that in some patients with TGBM nephropathy, progressive renal insufficiency may develop. We recommend a more vigilant approach in patients with TGBM nephropathy, especially if proteinuria is present.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45de65f54ab2d689759b113c6688e88a https://doi.org/10.1097/00007611-200207000-00023 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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