Absence of intestinal microbiota increases beta-cyclodextrin stimulated reverse cholesterol transport

Autor: Rima H. Mistry, Uwe J. F. Tietge, Henkjan J. Verkade
Přispěvatelé: Center for Liver, Digestive and Metabolic Diseases (CLDM), Lifestyle Medicine (LM)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Cardiovascular disease prevention
chemistry.chemical_compound
Feces
Bile
BILE-ACIDS
EXCRETION
PLASMA
Microbiota
Reverse cholesterol transport
beta-Cyclodextrins
SR-BI
Cardiovascular disease
Nutrition Lipids
Sterols
Cholesterol
Liver
lipids (amino acids
peptides
and proteins)
Female
Biotechnology
medicine.drug
medicine.medical_specialty
EZETIMIBE
Biology
METABOLISM
Excretion
Bile Acids and Salts
beta-cyclodextrin
NUCLEAR RECEPTOR
03 medical and health sciences
Ezetimibe
Internal medicine
medicine
Animals
LACTOBACILLUS-ACIDOPHILUS
Beta (finance)
Germ-free
COMPLEXATION
Lipid metabolism
Biological Transport
Metabolism
Atherosclerosis
Lipid Metabolism
Sterol
Gastrointestinal Microbiome
Mice
Inbred C57BL
MICE
030104 developmental biology
Endocrinology
Prebiotics
chemistry
Food Science
Zdroj: Circulation, 134(supplement 1):15581. LIPPINCOTT WILLIAMS & WILKINS
Molecular Nutrition & Food Research, 61(5):1600674. Wiley
ISSN: 1613-4125
0009-7322
Popis: Scope: Non-digestible oligosaccharides are used as prebiotics for perceived health benefits, among these modulating lipid metabolism. However, the mechanisms of action are incompletely understood. The present study characterized the impact of dietary beta-cyclodextrin (beta CD, 10%, w/w), a cyclic oligosaccharide, on sterol metabolism and reverse cholesterol transport (RCT) in conventional and also germ-free mice to establish dependency on metabolism by intestinal bacteria.Methods and Results: In conventional beta CD-fed C57BL/6J wild-type mice plasma cholesterol decreased significantly (-40%, pConclusion: In summary, this study demonstrates that beta CD lowers plasma cholesterol levels and increases fecal cholesterol excretion from a RCT-relevant pool. Intestinal bacteria decrease the impact of beta CD on RCT. These data suggest that dietary beta CD might have cardiovascular health benefits.
Databáze: OpenAIRE
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