Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals
| Autor: | Gyl Henrique Albrecht Ramos, Julie Massayo Maeda Oda, Roberta Losi Guembarovski, Iglenir J. Cavalli, Benedito Valdecir de Oliveira, Kalil Alves de Lima, Sandra Odebrecht Vargas Nunes, Mateus Nóbrega Aoki, Enilze Maria de Souza Fonseca Ribeiro, Maria Angelica Ehara Watanabe, Marlene Silva Bardi Gonçalves |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Transcriptional Activation Serotonin medicine.medical_specialty Genotype Pharmacology General Biochemistry Genetics and Molecular Biology Serotonin secretion Nicotine Gene Frequency Internal medicine medicine Humans Allele Allele frequency Alleles Serotonin transporter Aged Serotonin Plasma Membrane Transport Proteins Polymorphism Genetic biology Genome Human business.industry Smoking Case-control study Cancer Tobacco Use Disorder General Medicine Middle Aged medicine.disease Endocrinology Case-Control Studies Carcinoma Squamous Cell biology.protein Electrophoresis Polyacrylamide Gel Mouth Neoplasms business Brazil medicine.drug |
| Zdroj: | Clinical and Experimental Medicine. 12:13-19 |
| ISSN: | 1591-9528 1591-8890 |
| DOI: | 10.1007/s10238-011-0140-y |
| Popis: | The serotonergic system may be involved in smoking behavior since the intake of nicotine increases serotonin secretion in the CNS. Moreover, evidence supporting the beneficial effect of selective serotonin reuptake for quitting smoking suggesting that the serotonin transporter (5-HTT) is a plausible target for the understanding and elucidation of smoking behavior. The transcriptional activity of its human gene (SLC6A4) is modulated by a polymorphism described in the second intron, the STin2 VNTR, which thus may interfere with 5-HTT synthesis. In this study was analyzed the polymorphism STin2 VNTR of 60 smokers male patients diagnosed for oral carcinoma, 61 male smokers without cancer and 65 non-smoker healthy blood donors. The STin2. 9 allele carriers were more present in smoker groups (with cancer and without cancer, respectively) than in the non-smoker (OR = 7.11, 95% CI = 0.83-60.91 and OR = 24.73; IC 95% = 3.17-192.66). Conversely, individuals carrying allele 10 were more prevalent in non-smokers compared with smokers (oral cancer patients and individuals without cancer, respectively), showing a protective factor of this allele (OR = 0.56; 95% CI = 0.24-1.33 and OR = 0.46; 95% CI = 0.20-1.07). This is the first report of a study assessing the importance of STin2 VNTR smoking behavior in Brazilian individuals and the association of STin2. 9 allele carriers in nicotine dependence. It is suggested that individuals with low serotonin concentration in the central nervous system, probably due to the presence of the allele for high expression of 5-HTT,especially STin2. 9, were more susceptible to nicotine dependence. Moreover, individuals with the 10 allele might have less risk for nicotine dependence. |
| Databáze: | OpenAIRE |
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