Alcohol Drinking Increased the Risk of Advanced Colorectal Adenomas
| Autor: | Ji Hyun Lee, Young Kwan Jo, Byung Kwan Son, Sang Bong Ahn, Seung Chan Kim, Yun Ju Jo, Choon Sik Seon, Hye Jin Lim, Seong Hwan Kim, Young Sook Park, Yoon Kyung Song |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Risk
medicine.medical_specialty Pathology Adenoma Colorectal cancer lcsh:Medicine Alcohol Alcohol drinking Colorectal adenoma Gastroenterology chemistry.chemical_compound Internal medicine Advanced colorectal adenoma medicine Colonoscopic Polypectomy lcsh:RC799-869 Liver diseases alcoholics Life style business.industry lcsh:R Odds ratio medicine.disease chemistry lcsh:Diseases of the digestive system. Gastroenterology Original Article business Alcohol consumption |
| Zdroj: | Intestinal Research Intestinal Research, Vol 13, Iss 1, Pp 74-79 (2015) |
| ISSN: | 2288-1956 1598-9100 |
| Popis: | Background/aims Age, sex, gene and life style are modulating risks for colon cancer. Although alcohol intake may impact on colorectal adenoma, clear association has not been established yet. We aimed to investigate effects of alcohol consumption on the characteristics of colorectal adenoma. Methods Patients who underwent colonoscopic polypectomy of colorectal adenoma in the department of gastroenterology of Eulji hospital through 2005 to 2012, having both blood tests and ultrasound or abdominal CT examination were enrolled. The alcohol drinking patients were subdivided into normal or abnormal laboratory group, and alcoholic liver diseases group. Results 212 patients with colorectal adenoma were analyzed; advanced adenoma and multiple adenoma were found in 68 (32.0%) and 79 (37.2%) patients. When compared to the nondrinker group (120/212 patients), the alcohol drinker group (92/212 patients) represented significantly high odds ratios (ORs) for advanced adenoma (OR, 2.697; P=0.002), and multiple adenoma (OR, 1.929; P=0.039). Among alcohol drinker (92 patients), the ORs of advanced adenoma were 6.407 (P=0.003) in alcoholic liver diseases group (17 patients), 3.711 (P=0.002) in the alcohol drinker with abnormal lab (24 patients), and 2.184 (P=0.034), in the alcohol drinker with normal lab (51 patients) compared to nondrinker group. Conclusions This study showed that alcohol drinking may influence on the development of advanced colorectal adenoma and multiplicity. Especially in the group with alcoholic liver diseases and with abnormal lab presented significantly higher ORs of advanced adenoma. |
| Databáze: | OpenAIRE |
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