Melatonin Stimulates Epithelium Migration in Wound Models In Vitro and In Vivo
| Autor: | V. Y. Brodsky, D. S. Lazarev, N. N. Butorina, Ekaterina A. Vorotelyak, O. S. Rogovaya, L. A. Mal’chenko |
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| Rok vydání: | 2019 |
| Předmět: |
Keratinocytes
Male 0301 basic medicine G(M1) Ganglioside General Biochemistry Genetics and Molecular Biology Andrology Melatonin Mice 03 medical and health sciences 0302 clinical medicine Re-Epithelialization Cell Movement In vivo medicine Animals Humans Cells Cultured Cell Proliferation Skin Wound Healing Ganglioside integumentary system Chemistry Cell migration General Medicine In vitro Mice Inbred C57BL 030104 developmental biology Epithelium migration Cell culture Cattle Wound healing hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 168:242-246 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-019-04683-x |
| Popis: | We studied the effect of bovine brain gangliosides, individual ganglioside GM1, and melatonin on the rate of wound closure under in vitro conditions and the effect of melatonin on the rate of wound healing under in vivo conditions. It was shown that bovine brain gangliosides and melatonin reliably increased cell migration in the experimental wound model. This effect was detected when the cell cultures were treated with the test preparations after wound infliction and when the cultures of human keratinocytes were pretreated before wounding. Analysis of the effect of melatonin on the rate of wound healing in vivo showed that melatonin accelerated this process, especially at the middle stages corresponding to the proliferation phase (days 3-6 after surgery). Histological analysis revealed intensification of epidermal cell proliferation at the edges of the wound starting from day 4 after surgery. |
| Databáze: | OpenAIRE |
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