| Autor: |
B. Veyre, Jean-Alain Chayvialle, Jean-Alexis Grimaud, P. Paliard, R. Lambert, S. Peyrol |
| Rok vydání: |
1978 |
| Předmět: |
|
| Zdroj: |
Digestion. 18(5-6) |
| ISSN: |
0012-2823 |
| Popis: |
5 human cases of hepatoma have been chosen with respect to their different seric alpha-fetoprotein (alpha-FP) level and histological characters. Cells producing alpha-FP have been studied with specific horseradish-peroxidase-labelled immunoglobulins. Ultrastructural examination shows that alpha-FP is present in the cytoplasm of some tumoral hepatocytes. alpha-FP is also present in the cytoplasm of some rare nontumoral hepatocytes of a nonsecreting hepatoma. Ultrastructural differences are described in tumoral hepatocytes according to the grade of differentiation of the tumoral cell population. alpha-FP production appears to be restricted to moderately differentiated tumoral hepatocytes. These observations led to the hypothesis that production of alpha-FP may transiently develop either during the differentiation of tumoral hepatocytes, or during the new differentiation of nontumoral hepatocytes involved in a proliferative process. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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