Association of allograft inflammatory factor-1 gene polymorphism with rheumatoid arthritis
| Autor: | Stefania Giedrys-Kalemba, Violetta Dziedziejko, T. Szczepanik, Krzysztof Safranow, Mateusz Kurzawski, Marek Drozdzik, Andrzej Pawlik, Z. Borowiec‐Chłopek |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Genotype Immunology Biology Polymorphism Single Nucleotide Biochemistry Linkage Disequilibrium Arthritis Rheumatoid Gene Frequency Genetics medicine Humans Immunology and Allergy Genetic Predisposition to Disease Allele Patient group education Aged education.field_of_study Calcium-Binding Proteins Microfilament Proteins HLA-DR Antigens General Medicine Middle Aged medicine.disease DNA-Binding Proteins Increased risk Rheumatoid arthritis Antibody Formation Allograft inflammatory factor 1 biology.protein Female Gene polymorphism Antibody HLA-DRB1 Chains |
| Zdroj: | Tissue Antigens. 72:171-175 |
| ISSN: | 1399-0039 0001-2815 |
| DOI: | 10.1111/j.1399-0039.2008.01086.x |
| Popis: | Human allograft inflammatory factor-1 (AIF-1) is a cytoplasmic protein primarily identified in human and rat allografts, and data from several studies suggest an important role for AIF-1 in inflammatory processes. The aim of this study was to examine the association between AIF1 rs2269475:C>T polymorphism and rheumatoid arthritis (RA). AIF1 genotype was determined by means of the polymerase chain reaction–restriction fragment length polymorphism method in 276 White patients with RA and 236 healthy subjects. The frequency of the AIF1 rs2269475 TT genotype was significantly higher in the patients with RA than in the controls (OR = 5.59, 95% CI: 1.22–25.55). The frequency of T allele carriers in the patient group with RA was 31.9% vs 19.1% among controls (P = 0.0003). Moreover, the frequency of individuals positive for anti-cyclic citrullinated peptide (anti-CCP) antibodies was significantly elevated in the T allele carriers (OR = 8.82, 95% CI: 2.06–37.7). It is noteworthy that no significant linkage disequilibria between the AIF1 C/T and DRB1 alleles associated with RA development and anti-CCP antibody production [including the most frequent, i.e. *04 (32.7%) and *01 (23.5%)] (P > 0.1) were found. Our results show that the AIF1 rs2269475 T allele is associated with increased risk of RA development. Moreover, the frequency of individuals positive for anti-CCP antibodies is significantly increased among T allele carriers. |
| Databáze: | OpenAIRE |
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