Role of genetically determined production of immunoregulatory cytokines in immunopathogenesis of chronic viral hepatitides
| Autor: | Beloborodova Ei, V. V. Avdoshina, E V Beloborodova, V. I. Konenkov, V. V. Dortman, Tkachenko Sb, Naslednikova Io, N. V. Ryazantseva, A. P. Zima, V. V. Novitskii |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Adolescent Promoter Blood Donors General Medicine Hepatitis B Biology Hepatitis C Chronic Middle Aged medicine.disease Virology General Biochemistry Genetics and Molecular Biology Interleukin-10 Hepatitis B Chronic Genotype Immunology medicine Humans Interleukin-2 Female Interleukin-4 Allele Caucasian population Gene |
| Zdroj: | Bulletin of experimental biology and medicine. 143(6) |
| ISSN: | 0007-4888 |
| Popis: | Immunopathogenesis of chronic viral hepatitides was studied by modern immunological, molecular, genetic methods. We revealed an imbalance in the production of immunoregulatory cytokines by mononuclear leukocytes (primarily of the Th2 type). The risk of progression and chronic course of viral hepatitides in Caucasian population was associated with alleles of promoter regions −330G and −592A in the IL-2 and IL-10 genes, respectively, as well as with the T/T genotype of the polymorphic region C590T in the IL-4 gene. The C/C genotype of the IL-10 gene promoter region C592A was shown to be a factor determining resistance to long-term persistence of hepatitis B and C viruses. |
| Databáze: | OpenAIRE |
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