Hippocampal-striatal functional connectivity supports processing of temporal expectations from associative memory

Autor: Vincent van de Ven, Peter De Weerd, Henk Jansma, Sarach Kochs, Chanju Lee, Julia Lifanov
Přispěvatelé: Perception, RS: FPN CN 3, Section Eating Disorders and Obesity, RS: FPN CPS II, RS: FPN MaCSBio
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Time Factors
genetic structures
hippocampus
PREDICTION
striatum
DORSAL STRIATUM
SEGMENTATION
Hippocampus
Mnemonic
Striatum
Hippocampal formation
CA1
0302 clinical medicine
BASAL GANGLIA
temporal context
Research Articles
medicine.diagnostic_test
Functional connectivity
Putamen
05 social sciences
Content-addressable memory
TIME CELLS
Magnetic Resonance Imaging
Anticipation
Female
Psychology
Research Article
Adult
associative memory
Cognitive Neuroscience
DURATION
PLACE
050105 experimental psychology
03 medical and health sciences
Young Adult
Memory
medicine
Humans
0501 psychology and cognitive sciences
Motivation
PERCEPTION
SEQUENCES
functional connectivity
Association Learning
Corpus Striatum
nervous system
Nerve Net
Functional magnetic resonance imaging
Neuroscience
030217 neurology & neurosurgery
Zdroj: Hippocampus, 30(9), 926-937. Wiley
Hippocampus
ISSN: 1050-9631
Popis: The hippocampus and dorsal striatum are both associated with temporal processing, but they are thought to play distinct roles. The hippocampus has been reported to contribute to storing temporal structure of events in memory, whereas the striatum contributes to temporal motor preparation and reward anticipation. Here, we asked whether the striatum cooperates with the hippocampus in processing the temporal context of memorized visual associations. In our task, participants were trained to implicitly form temporal expectations for one of two possible time intervals associated to specific cue-target associations, and subsequently were scanned using 7T functional magnetic resonance imaging. During scanning, learned temporal expectations could be violated when the pairs were presented at either the learned or not-learned time intervals. When temporal expectations were not met during testing trials, activity in hippocampal subfields CA3/CA2 and CA1 decreased while right putamen activity increased, compared to when temporal expectations were met. Further, psycho-physiological interactions showed that functional connectivity between left CA1 and caudate, as well as between putamen and caudate, decreased when temporal expectations were not met. Our results indicate that the hippocampus and striatum cooperate to process implicit temporal expectation from mnemonic associations, with different but complementary contributions from caudate and putamen. Our findings provide further support for a hippocampal-striatal network in temporal associative processing.
Databáze: OpenAIRE
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