Elevated HSP90 associates with expression of HIF‐1α and p‐AKT and is predictive of poor prognosis in nasopharyngeal carcinoma
| Autor: | Juan Feng, Yuting Zhan, Junmi Lu, Lina Xu, Weiyuan Wang, Guiyuan Xie, Songqing Fan |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Poor prognosis Histology Lymph node metastasis Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Biomarkers Tumor otorhinolaryngologic diseases medicine Humans HSP90 Heat-Shock Proteins Lymph node Nasopharyngeal Carcinoma biology Proportional hazards model business.industry Late stage Nasopharyngeal Neoplasms General Medicine Middle Aged Hypoxia-Inducible Factor 1 alpha Subunit Prognosis medicine.disease Hsp90 stomatognathic diseases 030104 developmental biology medicine.anatomical_structure Nasopharyngeal carcinoma 030220 oncology & carcinogenesis biology.protein Cancer research Immunohistochemistry Female business Proto-Oncogene Proteins c-akt |
| Zdroj: | Histopathology. 75:202-212 |
| ISSN: | 1365-2559 0309-0167 |
| DOI: | 10.1111/his.13862 |
| Popis: | AIMS HSP90, as a molecular chaperone, has numerous substrate proteins, including HIF-1α and p-AKT, but the relationships among HSP90, HIF-1α and p-AKT have not been investigated in NPC. We examined and analysed the correlation between expression of HSP90, HIF-1α and p-AKT and clinicopathological features of NPC. METHODS We collected 445 cases of NPC and 54 cases of non-cancerous nasopharyngeal epithelia tissues, detected expression of HSP90, HIF-1α and p-AKT proteins in these tissues by immunohistochemistry. RESULTS The results indicated that overexpression of HSP90, HIF-1α and p-AKT in NPC was significantly higher than that in non-cancerous nasopharyngeal epithelia (P |
| Databáze: | OpenAIRE |
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