Effects of intestinal parasite infection on hematological profiles of pregnant women attending antenatal care at Debre Markos Referral Hospital, Northwest Ethiopia: Institution based prospective cohort study

Autor: Molla Yigzaw, Aster Shiferaw, Milkiyas Toru, Abtie Abebaw, Tebelay Dilnessa, Gebreselassie Demeke, Getachew Mengistu, Hylemariam Mihiretie Mengist
Rok vydání: 2020
Předmět:
Maternal Health
medicine.disease_cause
Biochemistry
Deworming
Intestinal Parasites
Medical Conditions
Pregnancy
Risk Factors
Prevalence
Medicine and Health Sciences
Prospective Studies
Intestinal Diseases
Parasitic
Prospective cohort study
Referral and Consultation
Multidisciplinary
biology
Obstetrics
Obstetrics and Gynecology
Anemia
Prenatal Care
Iron deficiency
Hematology
Medicine
Female
Ascaris lumbricoides
Anatomy
Research Article
Adult
medicine.medical_specialty
Adolescent
Birth weight
Science
Intestinal parasite
Young Adult
medicine
Parasitic Diseases
Animals
Humans
Hemoglobin
business.industry
Biology and Life Sciences
Proteins
medicine.disease
biology.organism_classification
Gastrointestinal Tract
Cross-Sectional Studies
Pregnancy Complications
Parasitic
Women's Health
Parasitology
Ethiopia
business
Parasitic Intestinal Diseases
Digestive System
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 5, p e0250990 (2021)
ISSN: 1932-6203
Popis: Background Intestinal parasitosis is a common disease that causes misery and disability in poor populations. The number of individuals affected is staggering. From two billion peoples who harbor parasites worldwide, 300 million suffer severe morbidity and more than 25% of pregnant women are infected with hookworm, which causes intestinal bleeding and blood loss, and has been most commonly associated with anemia. Intestinal parasite infection during pregnancy has been associated with iron deficiency, maternal anemia, and impaired nutritional status, as well as decreased infant birth weight. Objective This study aimed to assess the effects of intestinal parasite infection on hematological profiles of pregnant women attending antenatal care in Debre Markos Referral Hospital from December 2017 to February 2019. Method A prospective cohort study design was conducted among 94 intestinal parasite-infected pregnant women as an exposed group and 187 pregnant women free from intestinal parasite were used as a control group. The effect of intestinal parasites on hematological profiles of pregnant women was assessed at Debre Markos Referral Hospital antenatal care ward. Socio-demographic data and nutrition status were assessed by using structured questionnaires and mid-upper arm circumference (MUAC), respectively. Two ml of venous blood and 2 gm of stool samples were collected to analyze the hematological profiles and detect intestinal parasites, respectively. Wet mount and formol-ether concentration (FEC) techniques were used to detect intestinal parasites. Hematological profile was analyzed using Mind ray BC-3000 plus instrument. Data were double entered into EpiData version 3.1 software and exported to SPSS version 24 software for analysis. Results were presented using tables and graphs. Associations of hemoglobin levels with intestinal parasitic infections were determined using binary logistic regression models. P≤0.05 was considered statistically significant. The mean hematological profile difference between parasite-infected and parasite-free pregnant women was computed using independent t-test. Results In the present study, the predominant parasites identified were Entamoeba histolytica, hookworm, Giardia lamblia, Schistosoma mansoni, and Ascaris lumbricoides. About 8.2% of intestinal parasite-infected pregnant women had mild anemia while 4% had moderate anemia. Only 1.2% of intestinal parasite-free pregnant women developed moderate anemia. The mean HGB, HCT, MCV, MCH, and MCHC values of intestinal parasite-infected pregnant women were 12.8g/dl, 38.2%, 94.7fl, 33.1pg and 34.7g/dl, respectively. But the mean HGB, HCT, MCV, MCH and MCHC values of pregnant women who were free from intestinal parasites were 14.4 g/dl, 39.8%, 94.9fl, 33.9pg and 35.5g/dl, respectively. Anemia was strongly associated with hookworm (AOR = 21.29, 95%CI: 8.28–54.75, P.001), S.mansoni (AOR = 63.73, 95% CI: 19.15–212, P.001) and A.lumbricoide (AOR = 14.12, 95% CI 3.28–60.65, P.001). Conclusion Intestinal parasitic infection in pregnant women caused adverse impact on hematological profiles and was an independent predictor of anemia. Intestinal parasitic infection significantly decreased pregnant the level of HGB, HCT, MCV, MCH, and MCHC values. To minimize maternal anemia deworming could be good before pregnancy.
Databáze: OpenAIRE
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