Isatin inhibits the invasion of human neuroblastoma SH-SY5Y cells, based on microarray analysis
| Autor: | Yi Cao, Chuanxia Ju, Li Zhang, Wenyan Sun, Lin Hou, Xuefeng Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Isatin Cancer Research SH-SY5Y Cell Antineoplastic Agents Biochemistry 03 medical and health sciences chemistry.chemical_compound Neuroblastoma 0302 clinical medicine Cell Line Tumor Genetics medicine Autophagy Humans Neoplasm Invasiveness Molecular Biology Oncogene Chemistry Microarray analysis techniques TOR Serine-Threonine Kinases Articles Cell cycle medicine.disease invasion Molecular medicine Gene Expression Regulation Neoplastic 030104 developmental biology medicine.anatomical_structure Oncology mTOR signaling pathway 030220 oncology & carcinogenesis Cancer research Molecular Medicine |
| Zdroj: | Molecular Medicine Reports |
| ISSN: | 1791-3004 1791-2997 |
| Popis: | Neuroblastoma is the fourth most common type of extracranial malignant solid tumor in children. Isatin had been demonstrated to have inhibitory effects on neuroblastoma tumors in vivo and in vitro. The aim of the present study was to investigate the molecular mechanism related to the anti‑invasion effect of isatin on SH‑SY5Y cells using microarray analysis. The microarray data identified a number of genes to be differentially upregulated or downregulated between isatin‑treated cells and untreated controls. A large number of these genes were associated with the mTOR signaling pathway. The differentially expressed genes involved in the mTOR signaling pathway were verified further, as well as their downstream genes associated with autophagy. The results of the present study provided an insight into the potential inhibitory mechanism of isatin on neuroblastoma metastasis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |