Sex Steroids Up-Regulate E-Cadherin Expression in Hormone-Responsive Lncap Human Prostate-Cancer Cells
| Autor: | Giuseppe Carruba, Domenico D'amico, D. Miceli, Annalisa M. Montesanti, L. Polito, Rosaria Farruggio, Luigi Castagnetta, L. Comito |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Immunoblotting Biophysics Estrogen receptor Biology Biochemistry Prostate cancer chemistry.chemical_compound Internal medicine LNCaP medicine Humans Gonadal Steroid Hormones Fulvestrant Molecular Biology Estrogen receptor beta Estradiol Estrogen Antagonists Prostatic Neoplasms Androgen Antagonists Dihydrotestosterone Cell Biology Cadherins medicine.disease Androgen Immunohistochemistry Flutamide Endocrinology chemistry Estrogen Cancer cell Hydroxyflutamide |
| Zdroj: | Biochemical and Biophysical Research Communications. 212:624-631 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1995.2015 |
| Popis: | There is convincing evidence that a reduced expression of the E-cadherin cell-cell adhesion molecule associates with low tumor grade and poor prognosis in prostate cancer patients. However, little is known on how E-cadherin levels are regulated in human prostate cancer cells, We have inspected the effect of both androgens and estrogen on the expression of E-cadherin in the hormone-responsive LNCaP prostate tumor cell line, which is endowed with both androgen and estrogen receptors, Using both Dot Blot analysis and immunocytochemistry we have observed that either steroid significantly increased E-cadherin levels in these cells; this effect was not reversed by the simultaneous addition of the relevant antagonist, hydroxyflutamide or ICI-182,780. |
| Databáze: | OpenAIRE |
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