Evaluation of biomarkers of cell cycle arrest and inflammation in prediction of dialysis or recovery after kidney transplantation

Autor: Zoltan H. Endre, Philip W. Peake, Michaela Kelleher, Timothy J. Pianta, Nicholas A. Buckley, John W. Pickering
Rok vydání: 2015
Předmět:
Male
Vascular Endothelial Growth Factor A
medicine.medical_specialty
Pathology
Urinary system
medicine.medical_treatment
030232 urology & nephrology
Urology
Delayed Graft Function
030204 cardiovascular system & hematology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Predictive Value of Tests
Renal Dialysis
medicine
Humans
10. No inequality
Macrophage Migration-Inhibitory Factors
Chemokine CCL2
Kidney transplantation
Dialysis
Receptors
Scavenger
Tissue Inhibitor of Metalloproteinase-2
Transplantation
Kidney
business.industry
Acute kidney injury
Cell Cycle Checkpoints
Chemokine CXCL16
Middle Aged
medicine.disease
Kidney Transplantation
3. Good health
Insulin-Like Growth Factor Binding Proteins
Intramolecular Oxidoreductases
Vascular endothelial growth factor
medicine.anatomical_structure
chemistry
Female
Macrophage migration inhibitory factor
Inflammation Mediators
Trefoil Factor-3
Peptides
business
Chemokines
CXC
Biomarkers
Zdroj: Transplant International. 28:1392-1404
ISSN: 0934-0874
DOI: 10.1111/tri.12636
Popis: Summary Early prediction of delayed graft function (DGF) after kidney transplantation would facilitate patient management. Cell cycle arrest and inflammation are implicated in the pathogenesis of DGF. We assessed the utility of two novel acute kidney injury (AKI) biomarkers, urinary tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7), and five inflammatory markers to predict DGF following deceased-donor kidney transplantation. Serial urine concentrations of TIMP-2 and IGFBP7 were measured immediately after transplantation in 56 recipients along with vascular endothelial growth factor-A (VEGF-A), macrophage migration inhibitory factor (MIF), monocyte chemotactic protein-1 (MCP-1), trefoil factor 3 (TFF3) and chemokine (C-X-C) ligand 16 (CXCL16). Delayed graft function (DGF) was defined as requirement for dialysis within 7 days. Integrated discrimination improvement analysis was used to evaluate whether these biomarkers enhanced prediction of DGF independently of a validated clinical risk prediction model. DGF occurred in 22 patients (39%). At 4 h after kidney reperfusion, the area under the receiver operator characteristic curve (AUC) for VEGF-A was good (AUC > 0.80); for TIMP-2, IGFBP7 and [TIMP-2] × [IGFBP7] fair (AUCs 0.70–0.79); and for MIF, MCP-1, TFF3 and CXCL16 poor (AUC
Databáze: OpenAIRE
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