Prepregnancy obesity is associated with lower psychomotor development scores in boys at age 3 in a low-income, minority birth cohort
| Autor: | Lori Hoepner, Pam Factor-Litvak, Virginia Rauh, Andrew Rundle, Amy Nichols, Frederica P. Perera, Beverly J. Insel, Elizabeth M. Widen |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Intelligence Medicine (miscellaneous) 030209 endocrinology & metabolism Overweight Bayley Scales of Infant Development Article 03 medical and health sciences Child Development 0302 clinical medicine Pregnancy Risk Factors Humans Medicine Obesity Prospective Studies Child Poverty Minority Groups Psychomotor learning business.industry Infant Newborn Infant medicine.disease Child development Gestational Weight Gain 030104 developmental biology Child Preschool Prenatal Exposure Delayed Effects Female Underweight medicine.symptom business Weight gain Demography |
| Zdroj: | J Dev Orig Health Dis |
| ISSN: | 2040-1752 2040-1744 |
| Popis: | Whether maternal obesity and gestational weight gain (GWG) are associated with early-childhood development in low-income, urban, minority populations, and whether effects differ by child sex remain unknown. This study examined the impact of prepregnancy BMI and GWG on early childhood neurodevelopment in the Columbia Center for Children’s Environmental Health Mothers and Newborns study. Maternal prepregnancy weight was obtained by self-report, and GWG was assessed from participant medical charts. At child age 3 years, the Psychomotor Development Index (PDI) and Mental Development Index (MDI) of the Bayley Scales of Infant Intelligence were completed. Sex-stratified linear regression models assessed associations between prepregnancy BMI and pregnancy weight gain z-scores with child PDI and MDI scores, adjusting for covariates. Of 382 women, 48.2% were normal weight before pregnancy, 24.1% overweight, 23.0% obese, and 4.7% underweight. At 3 years, mean scores on the PDI and MDI were higher among girls compared to boys (PDI: 102.3 vs. 97.2, P = 0.0002; MDI: 92.8 vs. 88.3, P = 0.0001). In covariate-adjusted models, maternal obesity was markedly associated with lower PDI scores in boys [b = −7.81, 95% CI: (−13.08, −2.55), P = 0.004], but not girls. Maternal BMI was not associated with MDI in girls or boys, and GWG was not associated with PDI or MDI among either sex (all-P > 0.05). We found that prepregnancy obesity was associated with lower PDI scores at 3 years in boys, but not girls. The mechanisms underlying this sex-specific association remain unclear, but due to elevated obesity exposure in urban populations, further investigation is warranted. |
| Databáze: | OpenAIRE |
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