A study on the effect of phthalate esters and their metabolites on idiopathic infertile males
| Autor: | Rashmi Rana, Shikha Joon, Nayan K. Mohanty, Arun Kumar Jain |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Infertility endocrine system Urology Phthalic Acids 030232 urology & nephrology Male infertility Andrology 03 medical and health sciences Semen quality chemistry.chemical_compound 0302 clinical medicine Endocrinology Blood serum medicine Humans Infertility Male Sperm motility 030219 obstetrics & reproductive medicine urogenital system business.industry Phthalate Esters Environmental Exposure General Medicine Environmental exposure medicine.disease Sperm Semen Analysis chemistry Sperm Motility business |
| Zdroj: | Andrologia. 52 |
| ISSN: | 1439-0272 0303-4569 |
| DOI: | 10.1111/and.13720 |
| Popis: | Phthalate plasticisers in medical, cosmetic and consumer products might pose serious health implications in humans including infertility. We sought to investigate the correlation, if any, between the phthalates and their metabolites and sperm quality parameters, and male infertility. Phthalate esters (15) and their metabolites (5) were estimated in the blood serum and urine samples from the age-matched 152 infertile and 75 fertile males using gas chromatography (GC) and high-performance liquid chromatography (HPLC). Finally, the data were analysed to correlate phthalate exposure and semen quality parameters in the infertility group. The estimated levels of DEHP, DBP, DIBP, BEHIP, BPBG, DPP, DIOP, DIHP, DMP, DINP, BIOP, DMOP and DICHP were significantly higher in the infertile males compared to the fertile males (p < .05 or p < .01). However, these were not found to be associated with the semen quality parameters (sperm count, motility and sperm morphology). Similarly, HPLC data revealed that the associations between semen parameters (sperm count, sperm motility and sperm morphology) and phthalate metabolite (MEHP and MBP) concentrations in urine samples from the infertile males were mostly unremarkable or statistically nonsignificant. Conclusively, environmental exposure to phthalates and their impacts on male infertility were statistically insignificant in our study groups. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|