Residues of 2-hydroxy-3-phenylpyrazine, a degradation product of some β-lactam antibiotics, in environmental water in Vietnam

Autor: Yoshimasa Yamamoto, Le Viet Ha, Khong Thi Diep, Yoshinori Sumimura, Tran Minh Phu, Nguyen Thanh Phuong, Nguyen Nam Thang, Minae Warisaya, Nguyen Van Sy, Megumi Asayama, Tran Thi Tuyet Hoa, Kazumasa Hirata, Pham Ngoc Khai, Le Hong Dung, Le Danh Tuyen, Kazuo Harada
Rok vydání: 2017
Předmět:
0301 basic medicine
Environmental Engineering
medicine.drug_class
Health
Toxicology and Mutagenesis
Antibiotics
Aquaculture
010501 environmental sciences
beta-Lactams
Tandem mass spectrometry
01 natural sciences
Water Purification
03 medical and health sciences
chemistry.chemical_compound
Residue (chemistry)
Rivers
Environmental water
Tandem Mass Spectrometry
Liquid chromatography–mass spectrometry
Ampicillin
medicine
Environmental Chemistry
0105 earth and related environmental sciences
Geography
biology
Solid Phase Extraction
Public Health
Environmental and Occupational Health
Reproducibility of Results
Water
General Medicine
General Chemistry
biology.organism_classification
Pollution
Drug Residues
Anti-Bacterial Agents
030104 developmental biology
Vietnam
chemistry
Pyrazines
Environmental chemistry
Lactam
Water Pollutants
Chemical
Bacteria
Chromatography
Liquid
medicine.drug
Zdroj: Chemosphere. 172:355-362
ISSN: 0045-6535
DOI: 10.1016/j.chemosphere.2016.12.156
Popis: Antibiotic-resistant bacteria have become a serious problem worldwide, caused in part by the excessive use and discharge of antibiotics into the environment. Ampicillin (ABPC) is a widely used antibiotic. However, this chemical rapidly decomposes in water containing divalent cations like Ca2+ and Mg2+, thus, detection of ABPC in environmental water is difficult. This study was carried out to evaluate the presence of 2-hydroxy-3-phenylpyrazine (HPP), one of the degradation products of ABPC and β-lactam antibiotics with an ABPC substructure, in environmental water. An analytical method for HPP monitoring in environmental water was developed using liquid chromatography/tandem mass spectrometry. The analyte was extracted from water samples and enriched using a solid-phase extraction cartridge. The quantification limit was 1 ng L−1. The HPP recovery rates from spiked water samples of 25 and 125 ng L−1 were 84.1 and 86.1%, respectively. The method was then used to determine HPP residue levels in 98 environmental water samples from rivers, household ponds, and aquacultural ponds in Vietnam. HPP residues were detected in 60 samples. The HPP detection rates in rivers and household ponds were 42 and 79%, respectively. HPP was not detected in aquacultural ponds. HPP residue concentrations in the samples ranged from 1.3 to 413.3 ng L−1. The residue levels in rivers flowing through city centres were higher than levels in other sampling locations. The findings of this study suggest that HPP is a promising marker for assessing the discharge of ABPC and β-lactam antibiotics with an ABPC substructure into the environment around sampling sites.
Databáze: OpenAIRE
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