In vitro anti-trypanosomal potential of kaurane and pimarane semi-synthetic derivatives

Autor:	Lizandra Guidi Magalhães, Ana Carolina Ferreira Soares Rocha, Marcela M da Silva, Pedro Y. Kovatch, Daniele da Silva Ferreira, Mariana Cintra Pagotti, Gustavo Oliveira Morais, Vladimir Constantino Gomes Heleno, Viviane Rodrigues Esperandim
Rok vydání:	2020
Předmět:	010405 organic chemistry Chemistry Stereochemistry Organic Chemistry Plant Science 01 natural sciences Biochemistry In vitro 0104 chemical sciences Analytical Chemistry Semi synthetic Pimarane Diterpenes 010404 medicinal & biomolecular chemistry Kaurane Diterpenes
Zdroj:	Natural Product Research. 36:875-884
ISSN:	1478-6427 1478-6419
DOI:	10.1080/14786419.2020.1837824
Popis:	As part of the search for anti-trypanosomal agents, this work presents the production of sixteen derivatives. All of them were obtained from two natural diterpenes, one with kaurane skeleton (ent-kaurenoic acid) and other with a pimarane skeleton (ent-pimaradienoic acid). Then, the eighteen compounds were assayed against epimastigote form of Trypanosoma cruzi, with the derivatives showing increase of activity in relation to their precursors. Moreover, the most active derivative presented an IC50 50 = 9.8 µM), used as control. The esterification of acid diterpenes showed to be an interesting way in the search for anti-trypanosomal agents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450896999fb27f3fb7fd0fee9fade4c3 https://doi.org/10.1080/14786419.2020.1837824 Zobrazit plný text záznamu