Scleromatous Changes in an Abdominal Wall Graft: Graft-Versus-Graft Disease, or Chronic Graft Rejection?
| Autor: | M. Shane Chapman, Dorothea T. Barton, Daniel B Wimmer, Daniel P. Croitoru, Gregory D Seidel, Nicholas J. Olson, Konstantinos Linos |
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| Rok vydání: | 2017 |
| Předmět: |
Graft Rejection
medicine.medical_specialty Time Factors Biopsy Graft vs Host Disease Dermatology Disease 030230 surgery Pathology and Forensic Medicine Diagnosis Differential Abdominal wall Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Dermis Predictive Value of Tests Humans Medicine Skin Sclerosis medicine.diagnostic_test business.industry Abdominal Wall Skin Transplantation General Medicine Surgery Chronic graft rejection Treatment Outcome surgical procedures operative medicine.anatomical_structure Predictive value of tests Chronic Disease Etiology Female Differential diagnosis business |
| Zdroj: | The American Journal of Dermatopathology. 39:53-55 |
| ISSN: | 0193-1091 |
| DOI: | 10.1097/dad.0000000000000625 |
| Popis: | Abdominal wall transplants are relatively new procedures that are frequently performed in conjunction with multivisceral transplants. The skin of the abdominal wall transplant is often the first site for graft rejection to manifest itself. Prompt recognition can lead to appropriate treatment before the involvement of the underlying viscera. However, the signs of graft rejection are nonspecific and can overlap with other entities. We present a case of a patient who received a multivisceral and abdominal wall transplant from 2 different donors, who presented with acute and eventually chronic graft rejection of the abdominal wall graft. Serial biopsies performed during the course of her treatment demonstrated progressive sclerotic changes in the dermis. Because these changes were confined to the abdominal wall graft, they could represent either chronic graft rejection or graft-versus-graft disease. To date, graft-versus-graft disease has not been documented in these patients. This case illustrates the possibility that patients with multidonor transplants may be at an increased risk for graft failure secondary to multiple potential etiologies. |
| Databáze: | OpenAIRE |
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