A new dermocosmetic containing retinaldehyde, delta-tocopherol glucoside and glycylglycine oleamide for managing naturally aged skin: results from in vitro to clinical studies
| Autor: | Christine Coutanceau, Daniel Bacqueville, Hélène Duplan, Laure Duprat, Sandrine Bessou-Touya, Marie-José Haure, Valérie Mengeaud, Nathalie Castex-Rizzi, Patrick Bogdanowicz, Céline Rouvrais |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oleamide formulation Human skin Dermatology Pharmacology Skin Aging Extracellular matrix 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dermis delta-tocopherol glucoside Medicine preclinical aged skin model Original Research integumentary system biology business.industry glycylglycine oleamide Fibulin 030104 developmental biology medicine.anatomical_structure Biochemistry chemistry Clinical Cosmetic and Investigational Dermatology statistics retinaldehyde biology.protein business Elastin Ex vivo |
| Zdroj: | Clinical, Cosmetic and Investigational Dermatology |
| ISSN: | 1178-7015 |
| Popis: | Céline Rouvrais,1,* Daniel Bacqueville,2,* Patrick Bogdanowicz,2,* Marie-José Haure,2 Laure Duprat,2 Christine Coutanceau,3 Nathalie Castex-Rizzi,2 Hélène Duplan,2 Valérie Mengeaud,1 Sandrine Bessou-Touya2 1Clinical Skin Research Center, 2Department of Pharmacology, Pierre Fabre Dermo-Cosmétique, Toulouse, 3Laboratoire Dermatologique Avène, Lavaur, France *These authors contributed equally to this work Introduction: Natural aging of skin tissues, the addition of the cumulative action of the time and radiation exposure result in skin atrophy, wrinkles and degeneration of the extracellular matrix (ECM). The aim of the study was to investigate the beneficial effect of a combination containing retinaldehyde (RAL), delta-tocopherol glucoside (delta-TC) and glycylglycine oleamide (GGO) and of a dermocosmetic containing the combination. Materials and methods: The protective effect of the combination was assessed through invitro gene expression of ultraviolet (UV)-irradiated fibroblasts. A skin aging assay using UV light on ex vivo skin samples and a clinical study conducted in 36 women aged from 35 to 55years with a minimum of level 4 to a maximum of level 6 on the crow’s feet photoscale assessed the antiaging effect of the dermocosmetic. Results: When added to UV-irradiated fibroblasts, the combination substantially improved the ECM in activating the elastin fiber production (fibrillin 2, fibulin 1 and 5 and lysyl oxidase-like2) as well as that of proteins involved in the cellular ECM interactions (integrin β1, paxillin and actin a2). An ex vivo photodamaged human skin model showed that the dermocosmetic formulation containing the combination of the active ingredients protected the elastic network against UV-induced alterations including both elastin and fibrillin-rich fibers in the dermis. A daily application of the dermocosmetic for 2months on naturally aged skin resulted in a statistically significant improvement (p |
| Databáze: | OpenAIRE |
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