Moderate Exercise Training Induces ROS-Related Adaptations to Skeletal Muscles
| Autor: | Arsenio Veicsteinas, Stefania Fulle, Silvia Belia, S. di Tullio, Provvidenza Maria Abruzzo, Fabio Esposito, Cosetta Marchionni, Marina Marini |
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| Přispěvatelé: | Abruzzo PM, Esposito F, Marchionni C, di Tullio S, Belia S, Fulle S, Veicsteinas A, Marini M |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Satellite Cells Skeletal Muscle Muscle Fibers Skeletal Physical Therapy Sports Therapy and Rehabilitation Biology medicine.disease_cause Antioxidants Desmin Muscle hypertrophy Myoblasts Rats Sprague-Dawley Downregulation and upregulation Internal medicine medicine Animals Receptors Tumor Necrosis Factor Type II Myocyte HSP70 Heat-Shock Proteins Orthopedics and Sports Medicine Muscle Skeletal Cell Proliferation MUSCLE PLASTICITY chemistry.chemical_classification Calcium metabolism Reactive oxygen species Physical Education and Training Hyperplasia medicine.disease Adaptation Physiological OXIDATIVE STRESS AND SIGNALLING Rats Up-Regulation Oxidative Stress Endocrinology chemistry SLOW- AND FAST-TWITCH MUSCLES Calcium Reactive Oxygen Species MODERATE AEROBIC TRAINING Oxidative stress |
| Zdroj: | International Journal of Sports Medicine. 34:676-687 |
| ISSN: | 1439-3964 0172-4622 |
| DOI: | 10.1055/s-0032-1323782 |
| Popis: | Aim of the present work was the evaluation of the effects of moderate exercise training on two skeletal muscles differing for fibre-type composition, Tibialis Anterior (TA) and Soleus (SOL). Fibre adaptations, including their metabolic shift and mechanisms underlying proliferation and differentiation, oxidative stress markers, anti-oxidant and cytoprotective molecules, activity of Ca2+-handling molecules were examined. Six male 2-month-old rats trained on a treadmill for 1 h/day, 3 days/week, 14 weeks, reaching 30 m/min at the end of training. Six age-matched sedentary rats served as controls. Rats were sacrificed 24 h after the last training session. Muscle Regulatory Factors increased in both muscles, activating satellite cell proliferation, which led to moderate hypertrophy in SOL and to moderate hyperplasia in TA, where the upregulation of desmin and TNFR2 expression suggests that myotube formation by proliferating myoblasts is somehow delayed. Changes leading to a more oxidative metabolism together with the upregulation of a number of antioxidant enzymes occurred in TA. HSP70i protein was upregulated in both SOL and TA, while oxidative stress markers increased in SOL alone. The status of ionic channels and pumps was preserved. We suggest that the increase in ROS, known to be associated with exercise, underlies most observed results. |
| Databáze: | OpenAIRE |
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