Reliable assessment of the incidence of childhood autoimmune hemolytic anemia
| Autor: | Rodolphe Thiébaut, Aude Kostrzewa, Guy Leverger, G. Coureau, Véronique Gilleron, Marthe-Aline Jutand, Cyrielle Beaubois, Julien Jeanpetit, Michel Jeanne, Helder Fernandes, Thierry Leblanc, Pierre Lauroua, Y Perel, Nathalie Aladjidi |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Databases Factual Disease 03 medical and health sciences 0302 clinical medicine Coombs test medicine Humans In patient Child Retrospective Studies medicine.diagnostic_test business.industry Incidence Infant Retrospective cohort study Hematology medicine.disease Confidence interval Coombs Test Oncology Child Preschool 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Cohort Female Anemia Hemolytic Autoimmune Autoimmune hemolytic anemia business 030215 immunology Pediatric population |
| Zdroj: | Pediatric Blood & Cancer. 64:e26683 |
| ISSN: | 1545-5009 |
| DOI: | 10.1002/pbc.26683 |
| Popis: | Background Childhood autoimmune hemolytic anemia (AIHA) is a rare and severe disease characterized by hemolysis and positive direct antiglobulin test (DAT). Few epidemiologic indicators are available for the pediatric population. The objective of our study was to reliably estimate the number of AIHA cases in the French Aquitaine region and the incidence of AIHA in patients under 18 years old. Procedure In this retrospective study, the capture–recapture method and log-linear model were used for the period 2000–2008 in the Aquitaine region from the following three data sources for the diagnosis of AIHA: the OBS'CEREVANCE database cohort, positive DAT collected from the regional blood bank database, and the French medico-economic information system. Results A list of 281 different patients was obtained after cross-matching the three databases; 44 AIHA cases were identified in the period 2000–2008; and the total number of cases was estimated to be 48 (95% confidence interval [CI]: 45–55). The calculated incidence of the disease was 0.81/100,000 children under 18 years old per year (95% CI 0.76–0.92). Conclusion Accurate methods are required for estimating the incidence of AIHA in children. Capture–recapture analysis corrects underreporting and provides optimal completeness. This study highlights a possible under diagnosis of this potentially severe disease in various pediatric settings. AIHA incidence may now be compared with the incidences of other hematological diseases and used for clinical or research purposes. |
| Databáze: | OpenAIRE |
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