Immunocytochemical Detection of Tumour Cells in the Thoracic Duct of Patients with an Adenocarcinoma of the Oesophagus
| Autor: | L.C.J.M. Lemaire, Huug Obertop, ten Kate Fj, van Lanschot Jj, van Sandick Jw |
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| Přispěvatelé: | Other departments |
| Rok vydání: | 2001 |
| Předmět: |
Male
Pathology medicine.medical_specialty Esophageal Neoplasms Immunocytochemistry Adenocarcinoma digestive system Thoracic duct Thoracic Duct Submucosa otorhinolaryngologic diseases medicine Hollow viscus Humans Aged business.industry digestive oral and skin physiology technology industry and agriculture Gastroenterology Middle Aged medicine.disease Immunohistochemistry digestive system diseases Lymphatic system medicine.anatomical_structure Lymphatic Metastasis Female Surgery Lymph business |
| Zdroj: | Digestive surgery, 18(4), 280-282. S. Karger AG |
| ISSN: | 1421-9883 0253-4886 |
| DOI: | 10.1159/000050152 |
| Popis: | Background: Compared to other hollow viscus organs, the oesophagus has a unique anatomy in which lymphatic channels are abundantly present in the mucosa and submucosa. It has been hypothesized that tumour cells can directly disseminate from these superficial layers into the thoracic duct without passing juxta-tumoral lymph nodes. We investigated whether tumour cells of an oesophageal carcinoma could be detected in the thoracic duct during operative manipulation. Methods: In patients with an adenocarcinoma of the oesophagus and/or gastro-oesophageal junction, undergoing a transthoracic resection with two-field lymphadenectomy, lymph was collected and cells were immunostained. Results: Tumour cells could be detected in the thoracic duct lymph of only 1 out of 19 patients during operative manipulation. Conclusion: Peroperative data from this study do not support the hypothesis that oesophageal carcinoma readily metastasizes directly into the thoracic duct. |
| Databáze: | OpenAIRE |
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