Testing of a cumulative and aggregate exposure model using biomonitoring studies and dietary records for Italian vineyard spray operators

Autor: Stefan Mandić-Rajčević, Marc C. Kennedy, C. Richard Glass, Jacob D. van Klaveren, Richard J. Fussell, Hilko van der Voet, Silvia Fustinoni, Aida Turrini, Michel T. Hetmanski, Patrizia Riso, Angelo Moretto
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Male
010501 environmental sciences
Toxicology
01 natural sciences
Dermal exposure
chemistry.chemical_compound
Biomonitoring
Vitis
metabolites
education.field_of_study
Farmers
Probabilistic modelling
health
04 agricultural and veterinary sciences
General Medicine
Middle Aged
PE&RC
040401 food science
Diet Records
pesticide-residues
urinary concentrations
Biometris
Italy
Absorbed dose
Environmental Monitoring
Multiple exposure
Adult
Crops
Agricultural
Adolescent
Population
tebuconazole
Food Contamination
Air Pollutants
Occupational
Common assessment group
Consumer exposure
Occupational exposure
Vineyard
Young Adult
0404 agricultural biotechnology
Occupational Exposure
Humans
Pesticides
education
0105 earth and related environmental sciences
Tebuconazole
Aged
Models
Statistical
Pesticide residue
food
Pesticide Residues
Triazoles
Diet
Fungicides
Industrial
chemistry
Fruit
Environmental science
Food Science
Zdroj: Food and Chemical Toxicology 79 (2015)
Food and Chemical Toxicology, 79, 45-53
ISSN: 0278-6915
DOI: 10.1016/j.fct.2014.12.012
Popis: The need for improved tools to estimate the cumulative and aggregate exposure to compounds such as plant protection products (PPPs) is recognised in the EU Regulation 1107/2009. A new model has been developed to estimate the exposure within a population to single compounds or compounds within a Cumulative Action Group, considering dietary and non-dietary sources and multiple exposure routes. To test the model a field study was carried out in Italy with operators applying tebuconazole fungicides, with measurements of dermal exposure collected. Whole urine samples were collected and analysed to provide values for the absorbed dose of tebuconazole, with duplicate diet samples collected and analysed as a measure of dietary exposures. The model provided predicted values of exposure for combined dietary and non-dietary routes of exposures which were compared to the measured absorbed dose values based on urinary analysis. The model outputs provided mean daily exposure values of 1.77 (± 1.96) µg a.s./kg BW which are comparable to measured mean values from the biomonitoring field study of 1.73 (± 1.31) µg a.s./kg BW. To supplement the limited measurement data available, comparisons against other models were also made and found to be comparable.
Databáze: OpenAIRE
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