Targeting myeloid cells in the tumor sustaining microenvironment
| Autor: | Niklas Zimmer, Jonathan Schupp, Emily Trzeciak, Detlef Schuppan, Franziska K. Krebs, Andrea Tuettenberg |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Tumor microenvironment Immunology Cancer Tumor-associated macrophage Dendritic cell Biology medicine.disease 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure Neoplasms Cancer cell medicine Cancer research Tumor Microenvironment Animals Humans Tumor promotion Myeloid Cells Bone marrow Myelopoiesis Immunotherapy |
| Zdroj: | Cellular immunology. 343 |
| ISSN: | 1090-2163 |
| Popis: | Myeloid cells are the most abundant cells in the tumor microenvironment (TME). The tumor recruits and modulates endogenous myeloid cells to tumor-associated macrophages (TAM), dendritic cells (DC), myeloid-derived suppressor cells (MDSC) and neutrophils (TAN), to sustain an immunosuppressive environment. Pathologically overexpressed mediators produced by cancer cells like granulocyte-macrophage colony-stimulating- and vascular endothelial growth factor induce myelopoiesis in the bone marrow. Excess of myeloid cells in the blood, periphery and tumor has been associated with tumor burden. In cancer, myeloid cells are kept at an immature state of differentiation to be diverted to an immunosuppressive phenotype. Here, we review human myeloid cells in the TME and the mechanisms for sustaining the hallmarks of cancer. Simultaneously, we provide an introduction into current and novel therapeutic approaches to redirect myeloid cells from a cancer promoting to a rather inflammatory, cancer inhibiting phenotype. In addition, the role of platelets for tumor promotion is discussed. |
| Databáze: | OpenAIRE |
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