The effects of Origanum onites in streptozotocin-induced diabetes mellitus in rats
| Autor: | Oguzhan AYDEMIR, Elif Beyzanur POLAT, Khadija ALJESRI, Turgut TASKIN, Leyla BITIS, Hatice Kubra ELCIOGLU |
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| Přispěvatelé: | Aydemir O., Polat E. B. , Aljesri K., TAŞKIN T., BİTİŞ L., ELÇİOĞLU H. K. |
| Rok vydání: | 2022 |
| Předmět: |
PHARMACOLOGY & TOXICOLOGY
inflammatory cytokine Temel Bilimler Basic Pharmaceutics Sciences Origanum onites Life Sciences Life Sciences (LIFE) Sağlık Bilimleri liver Pharmacology and Therapeutics Genel Farmakoloji Toksikoloji ve Eczacılık Farmakoloji (tıbbi) Diabetes mellitus Temel Eczacılık Bilimleri Yaşam Bilimleri (LIFE) Farmakoloji ve Toksikoloji Yaşam Bilimleri Health Sciences FARMAKOLOJİ VE ECZACILIK oxidative stress Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Natural Sciences Eczacılık PHARMACOLOGY & PHARMACY |
| Zdroj: | Journal of Research in Pharmacy. 26:1884-1892 |
| ISSN: | 2630-6344 |
| Popis: | © 2022 Marmara University Press.Diabetes mellitus is a chronic disease characterized by decreased insulin synthesis and/or increased blood glucose due to insulin resistance. In this study, streptozotocin (STZ)-induced diabetic rats were evaluated and it was aimed to investigate the protective effects of Origanum onites L. (OO) against possible changes in these parameters. Male Sprague-Dawley rats weighing 300-400g were divided into three groups control (C), diabetes mellitus (DM) and diabetes mellitus + OO (OO group). DM was induced by administration of STZ 60 mg/kg dose intraperitoneally (i.p.) after 48 hours, rats with blood glucose values higher than 200 mg/dL were considered DM. Origanum extract was administered i.p. to the OO group at 50 mg/kg per day for 6 weeks. Serum AST, ALT, creatinine, and inflammatory cytokine levels were measured. MDA and GSH levels were measured in liver tissues. AST, ALT, creatinine, and MDA levels were found to be increased in the DM group, while a significant decrease in these levels was observed in the treated group. While GSH values fell in the DM group, a significant increase occurred in the OO group (n=6, p |
| Databáze: | OpenAIRE |
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