The effect of rhinovirus on airway inflammation in a murine asthma model
| Autor: | Jin Tack Kim, Hyun Hee Kim, Hwan Soo Kim, Jong-Seo Yoon, Hyun Sook Kim, Yoon Hong Chun, Joon Sung Lee, Eu Kyoung Lee, Huisu Lee, Eugene Kim, Kyongwon Bang, Sulmui Won |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Chemokine
Rhinovirus medicine.medical_treatment Pediatrics Proinflammatory cytokine Immune system medicine Immune response medicine.diagnostic_test biology business.industry lcsh:RJ1-570 Interleukin Exacerbation lcsh:Pediatrics Eosinophil respiratory system Asthma respiratory tract diseases Bronchoalveolar lavage medicine.anatomical_structure Cytokine Pediatrics Perinatology and Child Health Immunology biology.protein Tumor necrosis factor alpha Original Article business |
| Zdroj: | Korean Journal of Pediatrics, Vol 56, Iss 11, Pp 482-489 (2013) Korean Journal of Pediatrics |
| ISSN: | 2092-7258 1738-1061 |
| Popis: | Purpose: The aim of the present study was to investigate the differences in lower airway inflammatory immune responses, including cellular responses and responses in terms of inflammatory mediators in bronchoalveolar lavage fluid (BALF) and the airway, to rhinovirus (RV) infection on asthma exacerbation by comparing a control and a murine asthma model, with or without RV infection. Methods: BALB/c mice were intraperitoneally injected with a crude extract of Dermatophagoides farinae (Df ) or phosphate buffered saline (PBS) and were subsequently intranasally treated with a crude extract of Df or PBS. Airway responsiveness and cell infiltration, differential cell counts in BALF, and cytokine and chemokine concentrations in BALF were measured 24 hours after intranasal RV1B infection. Results: RV infection increased the enhanced pause (Penh) in both the Df sensitized and challenged mice (Df mice) and PBS-treated mice (PBS mice) (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|