Isolation of multidrug-resistant Haemophilus influenzae harbouring multiple exogenous genes from a patient diagnosed with acute sinusitis
| Autor: | Meiwa Shibata, Hiroyuki Shiro, Atsuko Shirai, Naoki Hara, Yoshiaki Natsume, Takeaki Wajima, Emi Tanaka, Norihisa Noguchi, Shoji Seyama |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Haemophilus Infections Gene Transfer Horizontal medicine.drug_class 030106 microbiology Antibiotics Microbial Sensitivity Tests medicine.disease_cause Microbiology Haemophilus influenzae 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Drug Resistance Multiple Bacterial Streptococcus pneumoniae Humans Medicine Pharmacology (medical) 030212 general & internal medicine Sinusitis Gene business.industry Streptococcus medicine.disease Anti-Bacterial Agents Multiple drug resistance Infectious Diseases Child Preschool Acute Disease Microbial Interactions Female business |
| Zdroj: | Journal of Infection and Chemotherapy. 25:385-387 |
| ISSN: | 1341-321X |
| Popis: | In paediatric patients, β-lactams and macrolides are widely used to treat acute otitis media and sinusitis, which are often caused by either Streptococcus pneumoniae or Haemophilus influenzae. However, resistant isolates have emerged and are becoming more prevalent. H. influenzae generally acquires antimicrobial resistance by mutation or by expression of β-lactamase. In this study, we isolated H. influenzae from a paediatric patient diagnosed with acute sinusitis. This strain harboured multiple exogenous resistance genes: blaTEM-1, mef(A) and tet(M). DNA sequencing suggested that both mef(A) and tet(M) had been transferred from S. pneumoniae or another Streptococcus. This typical outpatient had not been exposed to excessive levels of antibiotics and had no underlying diseases, strongly suggesting that this type of resistant isolate could become more prevalent. |
| Databáze: | OpenAIRE |
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