Development and performance evaluation of a dynamic phantom for biological dosimetry of moving targets
| Autor: | Gemmel, A., Bert, C., Saito, N., von Neubeck, Cläre, Iancu, G., Weyrather, W.K., Durante, M., Rietzel, E., K-Weyrather, W |
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| Přispěvatelé: | A., Gemmel, C., Bert, N., Saito, C., von Neubeck, G., Iancu, W. K., Weyrather, Durante, Marco, E., Rietzel |
| Rok vydání: | 2010 |
| Předmět: |
Materials science
Cell Survival Movement Medizin CHO Cells Imaging phantom Cricetulus Optics Cricetinae Perpendicular Animals Dosimetry Radiology Nuclear Medicine and imaging Irradiation Radiometry Cell survival Photons Models Statistical Radiological and Ultrasound Technology Phantoms Imaging business.industry Significant difference Reproducibility of Results Equipment Design Culture Media Mockup business Algorithms Beam (structure) |
| Zdroj: | Physics in Medicine and Biology. 55:2997-3009 |
| ISSN: | 1361-6560 0031-9155 |
| Popis: | A dynamic phantom has been developed to allow for measurement of 3D cell survival distributions and the corresponding distributions of the RBE-weighted dose (RBED) in the presence of motion. The phantom consists of two 96-microwell plates holding Chinese hamster ovary cells inside a container filled with culture medium and is placed on a movable stage. Basic biological properties of the phantom were investigated without irradiation and after irradiation with a carbon ion beam, using both a stationary (reference) exposure and exposure during motion of the phantom perpendicular to the beam with beam tracking. There was no statistically significant difference between plating efficiency measured in the microwells with and without motion (0.75) and values reported in the literature. Mean differences between measured and calculated cell survival for these two irradiation modes were within +/-5% of the target dose of 6 Gy (RBE). |
| Databáze: | OpenAIRE |
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