Development of fast disintegrating compressed tablets using amino acid as disintegration accelerator: evaluation of wetting and disintegration of tablet on the basis of surface free energy
| Autor: | Jinichi Fukami, Yasuo Yoshihashi, Asuka Ozawa, Etsuo Yonemochi, Katsuhide Terada |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Chemical Phenomena Surface Properties Glycine Oral cavity Excipients Hardness Drug Discovery Humans Solubility Amino Acids Particle Size Cellulose chemistry.chemical_classification Mouth Chromatography Chemistry Chemistry Physical General Chemistry General Medicine Surface energy Amino acid Chemical engineering Solvents Particle size Wetting Powders Dispersion (chemistry) Stearic Acids Tablets |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0009-2363 |
| Popis: | A fast disintegrating compressed tablet was formulated using amino acids, such as L-lysine HCl, L-alanine, glycine and L-tyrosine as disintegration accelerator. The tablets having the hardness of about 4 kgf were prepared and the effect of amino acids on the wetting time and disintegration time in the oral cavity of tablets was examined on the basis of surface free energy of amino acids. The wetting time of the tablets increased in the order of L-lysine HCl, L-alanine, glycine and L-tyrosine, whereas the disintegration time in the oral cavity of the tablets increased in the order of L-alanine, glycine, L-lysine HCl and L-tyrosine. These behaviors were well analyzed by the introduction of surface free energy. When the polar component of amino acid was large value or the dispersion component was small value, faster wetting of tablet was observed. When the dispersion component of amino acid was large value or the dispersion component was small value, faster disintegration of tablet was observed, expect of L-tyrosine tablet. The fast disintegration of tablets was explained by the theory presented by Matsumaru. |
| Databáze: | OpenAIRE |
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