Gastrografin can be detected in ex vivo biological specimens by dual-energy CT scanning
| Autor: | David A. Clark, Aleksandra Edmundson, Michael J. Solomon, Jit Pratap, John Coucher, Edward Yeoh, Tom Snow |
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| Rok vydání: | 2019 |
| Předmět: |
Serial dilution
Contrast Media Diatrizoate In Vitro Techniques 030218 nuclear medicine & medical imaging 03 medical and health sciences Biological specimen Feces 0302 clinical medicine Drug Stability medicine Humans Radiology Nuclear Medicine and imaging Diatrizoate Meglumine business.industry Phantoms Imaging Reproducibility of Results Iodine measurement Contrast medium Oncology 030220 oncology & carcinogenesis Dual energy ct Nuclear medicine business Tomography X-Ray Computed Ex vivo medicine.drug |
| Zdroj: | Journal of medical imaging and radiation oncologyReferences. 64(5) |
| ISSN: | 1754-9485 |
| Popis: | Background: Dual‐energy CT is able to distinguish between materials based on differences in X‐ray absorption at different X‐ray beam energies. The strong k‐edge photoelectric effect of materials with a high atomic number makes this modality ideal for identifying iodine‐containing compounds. We aim to evaluate dual‐energy CT for the detection of Gastrografin (GG) (diatrizoate, Bayer PLC, Reading, UK) enteric contrast medium and validate the conditions for the measurement in ex vivo samples. Methods: Dual‐energy CT acquisitions were performed to detect Gastrografin in serial dilutions of water, saline and body fluids. We also evaluated the stability of Gastrografin solutions over time at room temperature. Stool specimens were examined to validate the proposed study protocol for clinical applications. Results: Concentrations as low as 0.2% of Gastrografin were reproducibly detected in vitro and ex vivo samples by DECT, with linear readings ranging from 0.2% to 25% Gastrografin. Gastrografin was shown to be stable in ex vivo biological samples, and there was no difference in detection over time. Gastrografin was detected in stool specimens when administered orally. The detection curves followed the expected saturation effect at high concentrations of iodine. Conclusions: Dual‐energy CT offers a convenient, quick, reliable and reproducible method for detecting and quantifying the presence of Gastrografin in ex vivo clinical specimens. Biological solutions containing Gastrografin are stable over time. A minimum dilution level of 25% is suggested to avoid beam saturation and inaccurate results. |
| Databáze: | OpenAIRE |
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