Piconewton Mechanical Forces Promote Neurite Growth
| Autor: | Alfred Cuschieri, Gerardo F. Goya, María Pilar Calatayud, Francesca Falcone, Alessandro Falconieri, Vittoria Raffa, Sara De Vincentiis |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Neurite Mechanical Phenomena Biophysics Mechanical tension Neurite elongation Ferric Compounds PC12 Cells Biomechanical Phenomena 03 medical and health sciences Cell Behavior (q-bio.CB) Neurites Animals Growth cone Chemistry Mechanical force Rats 030104 developmental biology Neurite growth Cell Biophysics FOS: Biological sciences Quantitative Biology - Cell Behavior Nanoparticles |
| Zdroj: | Zaguán. Repositorio Digital de la Universidad de Zaragoza instname Biophysical Journal |
| ISSN: | 0006-3495 |
| DOI: | 10.1016/j.bpj.2018.10.009 |
| Popis: | Investigations over half a century have indicated that mechanical forces induce neurite growth - with neurites elongating at a rate of 0.1-0.3{\mu}mh^{-1} per pico-Newton (pN) of applied force - when mechanical tension exceeds a threshold, with this being identified as 400-1000 pN for neurites of PC12 cells. Here we demonstrate that there is no threshold for neurite elongation of PC12 cells in response to applied mechanical forces. Instead, this proceeds at the same previously identified rate, on the application of tensions with intensity below 1pN. This supports the idea of mechanical tension as an endogenous signal used by neurons for promoting neurite elongation. Comment: 16 pages, 3 figures |
| Databáze: | OpenAIRE |
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