Genetic variation and gene expression across multiple tissues and developmental stages in a non-human primate

Autor: Matthew J. Jorgensen, Giovanni Coppola, Ken Dewar, George M. Weinstock, Emily S. W. Wong, Joseph DeYoung, Chiara Sabatti, Scott C. Fears, Wesley C. Warren, David J. Jentsch, Lynn A. Fairbanks, Richard K. Wilson, Christine B. Peterson, Nelson B. Freimer, Anna J. Jasinska, Eleazar Eskin, Jay R. Kaplan, Allison E. Furterer, John Blangero, Thomas D. Dyer, Ivette Zelaya, Diego Villar, Vasily Ramensky, Yu S. Huang, Oi Wa Choi, Rita M. Cantor, Hannes Svardal, Roger P. Woods, Marina Bogomolov, Christopher A. Schmitt, Bronwen Aken, Yoav Benjamini, Rishi Nag, Paul Flicek
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Genotype
Quantitative Trait Loci
Genome-wide association study
Locus (genetics)
Hippocampal formation
Quantitative trait locus
Bioinformatics
Medical and Health Sciences
Polymorphism
Single Nucleotide
Article
Transcriptome
03 medical and health sciences
0302 clinical medicine
Gene expression
Genetic variation
Chlorocebus aethiops
Genetics
Animals
Humans
Vervet monkey
Polymorphism
030304 developmental biology
0303 health sciences
biology
Gene Expression Profiling
Human Genome
Brain
Genetic Variation
Single Nucleotide
Biological Sciences
biology.organism_classification
Gene expression profiling
030104 developmental biology
Phenotype
Evolutionary biology
Expression quantitative trait loci
030217 neurology & neurosurgery
Biotechnology
Developmental Biology
Genome-Wide Association Study
Zdroj: Nature genetics
Nature genetics, vol 49, iss 12
ISSN: 1546-1718
1061-4036
Popis: By analyzing multi-tissue gene expression and genome-wide genetic variation data in samples from a vervet monkey pedigree, we generated a transcriptome resource and produced the first catalogue of expression quantitative trait loci (eQTLs) in a non-human primate model. This catalogue contains more genome-wide significant eQTLs, per sample, than comparable human resources, and reveals sex and age-related expression patterns. Findings include a master regulatory locus that likely plays a role in immune function, and a locus regulating hippocampal long non-coding RNAs (lncRNAs), whose expression correlates with hippocampal volume. This resource will facilitate genetic investigation of quantitative traits, including brain and behavioral phenotypes relevant to neuropsychiatric disorders.
Databáze: OpenAIRE
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