Cervical cancer with ≤5 mm depth of invasion and >7 mm horizontal spread — Is lymph node assessment only required in patients with LVSI?
| Autor: | Valery E.P.P. Lemmens, Hans W. Nijman, Renée M.F. Ebisch, Kim G. G. van Kol, Ruud L.M. Bekkers, Maaike A. van der Aa, Hans H B Wenzel |
|---|---|
| Přispěvatelé: | Translational Immunology Groningen (TRIGR), Targeted Gynaecologic Oncology (TARGON), Obstetrie & Gynaecologie, RS: GROW - R2 - Basic and Translational Cancer Biology |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Uterine cervical neoplasms Survival CARCINOMA medicine.medical_treatment Lymph node metastasis Adenocarcinoma STAGE IA2 03 medical and health sciences 0302 clinical medicine SDG 3 - Good Health and Well-being Squamous cell carcinoma medicine Carcinoma Microinvasive Humans Neoplasm Invasiveness Lymph node Aged Retrospective Studies Cervical cancer business.industry Obstetrics and Gynecology Middle Aged medicine.disease LYMPHADENECTOMY Cancer registry 030104 developmental biology medicine.anatomical_structure METASTASES Oncology Depth of invasion 030220 oncology & carcinogenesis Lymphatic Metastasis Carcinoma Squamous Cell Lymphadenectomy Female Radiology Lymph Nodes business |
| Zdroj: | Gynecologic Oncology, 158(2), 282-286. ACADEMIC PRESS INC ELSEVIER SCIENCE Gynecologic Oncology, 158(2), 282-286. Elsevier Science |
| ISSN: | 0090-8258 |
| DOI: | 10.1016/j.ygyno.2020.04.705 |
| Popis: | Objective: Cervical cancer with ≤5 mm depth of invasion and >7 mm horizontal spread is classified FIGO IA instead of FIGO IB in the revised staging system, as horizontal spread is no longer considered. We aimed to determine the incidence of lymph node metastasis (LNM) and, consequently, the necessity of pelvic lymph node assessment. Methods: Patients diagnosed between January 2015 and May 2019 with cervical cancer FIGO (2009) stage IB with ≤5 mm depth of invasion and >7 mm horizontal spread, were identified from the Netherlands Cancer Registry. Associations between disease-characteristics and lymph node metastasis (LNM), and overall survival, were assessed. Results: Of 170 patients, six (3.5%) had LNM: 4/53 (7.6%) with adenocarcinoma and 2/117 (1.7%) with squamous cell carcinoma (p =.077). Four-year overall survival was 98.2%. LNM was observed more often in tumours with LVSI (4/43 patients, 9.3%) than without LVSI (2/117 patients, 1.7%) (p =.045). In adenocarcinoma with 3–5 mm depth of invasion LNM rate was 10% (4/40). None of the following tumours were observed with LNM: squamous cell carcinoma without LVSI (0/74); adenocarcinoma with |
| Databáze: | OpenAIRE |
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