Functional and structural insights on self-assembled nanofiber-based novel antibacterial ointment from antimicrobial peptides, bacitracin and gramicidin S
| Autor: | Denial Mahata, Octavio L. Franco, Diego O. Nolasco, Santi M. Mandal, Anupam Roy, Ludovico Migliolo |
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| Rok vydání: | 2014 |
| Předmět: |
Chemistry
Pharmaceutical In silico Antimicrobial peptides Nanofibers Gramicidin S Bacitracin Ointments chemistry.chemical_compound Drug Discovery medicine Pharmacology Bacteria biology Circular Dichroism Gramicidin Bacterial Infections biology.organism_classification Anti-Bacterial Agents Molecular Docking Simulation stomatognathic diseases chemistry Biochemistry Docking (molecular) Nanofiber Microscopy Electron Scanning Protein Multimerization medicine.drug |
| Zdroj: | The Journal of Antibiotics. 67:771-775 |
| ISSN: | 1881-1469 0021-8820 |
| Popis: | A novel antibacterial ointment using bacitracin, specific for Gram-positive bacteria, and gramicidin S, a highly toxic antibacterial peptide, was here developed showing broad-spectrum antibacterial activities against pathogenic strains with less toxicity after self-assembly into nanofiber structures. Such structures were confirmed with scanning electron microscopy and CD analyses. In addition, in silico studies using docking associated with molecular dynamics were carried out to obtain information about fiber structural oligomerization. Thus, the bacitracin and gramicidin S-based self-assembled nanopeptide ribbon may be a successful ointment formulation for bacterial infection control. |
| Databáze: | OpenAIRE |
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