Stabilisation of an amorphous form of ROY through a predicted co-former interaction

Autor: Jonathan W. Steed, Philip Anthony Corner, James F. McCabe, David J. Berry, J. Jonathan Harburn
Rok vydání: 2016
Předmět:
Zdroj: Chemical communications, 2016, Vol.52(39), pp.6537-6540 [Peer Reviewed Journal]
ISSN: 1364-548X
Popis: The highly polymorphic compound ROY, notorious for the colour of its crystals, was the subject of an optimised high-throughput ultrasound-based co-crystal screen. This screen involved a computational pre-screen which highlighted an interaction between ROY and the potential co-former pyrogallol. We have shown that the presence of pyrogallol stabilises the amorphous form of ROY, highlighting the potential for future prediction of co-amorphous behaviours.
Databáze: OpenAIRE