High-performance renal imaging with a radiolabeled, non-excretable chimeric fusion protein
| Autor: | Muhsin H Younis, Weibo Cai, Xiaoli Lan, Dawei Jiang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Vascular Endothelial Growth Factor A
Pathology medicine.medical_specialty Recombinant Fusion Proteins Medicine (miscellaneous) Renal function Receptors Fc single photon emission computed tomography (SPECT) Kidney Renal scintigraphy vascular endothelial growth factor (VEGF) renal scan Neonatal Fc receptor polybasic tag (PBT) Medicine Animals Humans nuclear medicine Tubular basement membrane Pharmacology Toxicology and Pharmaceutics (miscellaneous) Radioisotopes Tomography Emission-Computed Single-Photon neonatal Fc receptor business.industry Histocompatibility Antigens Class I Technetium Biological Transport Fusion protein Kidney imaging Tc-99m Renal imaging Editorial Renal physiology Radiopharmaceuticals business Tomography X-Ray Computed recombinant protein |
| Zdroj: | Theranostics |
| ISSN: | 1838-7640 |
| Popis: | Ideal nuclear imaging tracers should exhibit high target uptake and low background signal. Traditional renal scintigraphy and SPECT scans examine kidney function via static or dynamic tracing of radioactive probes in the kidneys. The lack of tracer affinity to specific biological processes and high background uptake from urinary excretion have added many difficulties to precision renal diagnosis. In this issue of Theranostics, Jin and colleagues innovatively devised a recombinant probe for preferential kidney imaging through targeting of tubular neonatal Fc receptor and proximal tubular basement membrane for sustained tubular reabsorption and accumulation. This work has broad implications regarding how an in depth understanding of physiology and pathology may be of service for tracer development, renal diagnosis, and disease theranostics. |
| Databáze: | OpenAIRE |
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