Association of gut-related metabolites with respiratory symptoms in COVID-19: A proof-of-concept study

Autor:	Muhammad Zubair Israr, Wadah Ibrahim, Andrea Salzano, Sarir Sarmad, Michael J. Wilde, Rebecca L. Cordell, Neil J. Greening, Christopher E. Brightling, Salman Siddiqui, Toru Suzuki
Rok vydání:	2022
Předmět:	Betaine Methylamines Nutrition and Dietetics gut microbiota Carnitine Endocrinology Diabetes and Metabolism COVID-19 Humans respiratory metabolomics Article Choline Gastrointestinal Microbiome
Zdroj:	Nutrition (Burbank, Los Angeles County, Calif.)
ISSN:	0899-9007
DOI:	10.1016/j.nut.2021.111585
Popis:	Gut-related metabolites have been linked with respiratory disease. The crosstalk between the gut and lungs suggests that gut health may be compromised in COVID-19. The aims of the present study were to analyze a panel of gut-related metabolites (acetyl-L-carnitine, betaine, choline, L-carnitine, trimethylamine, and trimethylamine N-oxide) in patients with COVID-19, matched with healthy individuals and patients with non-COVID-19 respiratory symptoms. As results, metabolites from this panel were impaired in patients with COVID-19 and were associated with the symptoms of breathlessness and temperature, and it was possible to differentiate between COVID-19 and asthma. Preliminary results showed that lower levels of betaine appeared to be associated with poor outcomes in patients with COVID-19, suggesting betaine as a marker of gut microbiome health.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d7983af6c1f0aa37fa9655d9c15d4b https://doi.org/10.1016/j.nut.2021.111585 Zobrazit plný text záznamu Full Text from ScienceDirect